Tchem HSD11B2 Corticosteroid 11-beta-dehydrogenase isozyme 2

Protein Summary

Description

Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• P80365
• A7LB28
• C5HTY7
• Q13194
• Q6P2G9
• Q8N439
• Q96QN8
• Q9UC50
• Q9UC51
• Q9UCW5
• Q9UCW6
• Q9UCW7
• Q9UCW8

Gene Name

• HSD11B2

Ensembl ID

• ENST00000326152
• ENSP00000316786
• ENSG00000176387

Symbol

• HSD11K
• SDR9C3
• AME
• AME1
• HSD2
• HSD11K
• SDR9C3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.87
biological term	0.86
disease	0.78
PubMedID	0.76
transcription factor	0.71

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Corticosteroid 11-beta-dehydrogenase Isozyme 2

Protein / Oxidoreductase / Dehydrogenase / Corticosteroid 11-beta-dehydrogenase Isozyme 2

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Corticosteroid 11-beta-dehydrogenase Isozyme 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 697.19   (req: < 5)

Gene RIFs: 154   (req: <= 3)

Antibodies: 275   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 697.19   (req: >= 5)

Gene RIFs: 154   (req: > 3)

Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4