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Tbio
HSCB
Iron-sulfur cluster co-chaperone protein HscB, mitochondrial

Protein Summary
Description
Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216027
  • ENSP00000216027
  • ENSG00000100209

Symbol
  • DNAJC20
  • HSC20
  • JAC1
  • HSC20
  • DNAJC20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
virus perturbation
0.85
transcription factor binding site profile
0.8
tissue sample
0.61
cellular component
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.74   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.74   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
ISCU
Tbio
Novelty:  0.0043097
Score:  0.998
Data Source:  STRINGDB
FXN
Tbio
Novelty:  0.00084064
Score:  0.993
Data Source:  STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
Score:  0.99
Data Source:  STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
Score:  0.989
Data Source:  STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.988
Data Source:  STRINGDB
GLRX5
Tbio
Novelty:  0.01166161
Score:  0.988
Data Source:  STRINGDB
GRPEL1
Tbio
Novelty:  0.00185346
Score:  0.982
Data Source:  STRINGDB
NFS1
Tbio
Family:  Enzyme
Novelty:  0.01274706
Score:  0.973
Data Source:  STRINGDB
DNAJC19
Tbio
Family:  Enzyme
Novelty:  0.02938164
Score:  0.971
Data Source:  STRINGDB
PMPCB
Tbio
Family:  Enzyme
Novelty:  0.0244013
Score:  0.965
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Mitochondrial iron-sulfur cluster biogenesis
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Metabolism
Mitochondrial iron-sulfur cluster biogenesis
Mitochondrial protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
4
5
6
97.7
red blood cell distribution width
4
4
5
95.5
sex hormone-binding globulin measurement
6
2
6
92.1
optic disc size measurement
3
2
3
90.6
heel bone mineral density
2
4
5
89.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
6
97.7
red blood cell distribution width
5
95.5
sex hormone-binding globulin measurement
6
92.1
optic disc size measurement
3
90.6
heel bone mineral density
5
89.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HscB mitochondrial iron-sulfur cluster cochaperone
VGNC:9923
458734
Macaque
HscB mitochondrial iron-sulfur cluster cochaperone
713734
Mouse
MGI:2141135
100900
Rat
RGD:1311005
360826
Dog
HscB mitochondrial iron-sulfur cluster cochaperone
VGNC:41796
477531
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HscB mitochondrial iron-sulfur cluster cochaperone
Macaque
HscB mitochondrial iron-sulfur cluster cochaperone
Mouse
Rat
Dog
HscB mitochondrial iron-sulfur cluster cochaperone
Publication Statistics
PubMed Score 74.74
PubMed score by year
PubTator Score 20.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title