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Tbio
HS6ST1
Heparan-sulfate 6-O-sulfotransferase 1

Protein Summary
Description
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259241
  • ENSP00000259241
  • ENSG00000136720

Symbol
  • HS6ST
  • HH15
  • HS6ST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
transcription factor binding site profile
0.76
PubMedID
0.71
tissue sample
0.69
transcription factor perturbation
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.13   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.13   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
HFE
Tbio
Novelty:  0.00042077
p_int:  0.978145359
p_ni:  0.021161692
p_wrong:  0.000692949
Data Source:  BioPlex
B3GNT3
Tbio
Family:  Enzyme
Novelty:  0.04325325
p_int:  0.973083754
p_ni:  0.020396237
p_wrong:  0.006520008
Score:  0.352
Data Source:  BioPlex,STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.96246278
p_ni:  0.03159705
p_wrong:  0.00594017
Data Source:  BioPlex
NRG1
Tbio
Novelty:  0.00095246
p_int:  0.95677649
p_ni:  0.034402501
p_wrong:  0.00882101
Data Source:  BioPlex
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.954469269
p_ni:  0.041585492
p_wrong:  0.003945239
Data Source:  BioPlex
PCSK1
Tchem
Family:  Enzyme
Novelty:  0.00315256
p_int:  0.929696001
p_ni:  0.069005751
p_wrong:  0.001298247
Score:  0.287
Data Source:  BioPlex,STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.920095287
p_ni:  0.006419184
p_wrong:  0.073485529
Data Source:  BioPlex
CRP
Tbio
Novelty:  0.00001517
p_int:  0.912883931
p_ni:  0.002982308
p_wrong:  0.084133761
Data Source:  BioPlex
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.899534496
p_ni:  0.003580583
p_wrong:  0.096884922
Data Source:  BioPlex
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.857956884
p_ni:  0.141324697
p_wrong:  0.000718419
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG biosynthesis
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
HS-GAG biosynthesis
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
76.1
lymphocyte percentage of leukocytes
1
1
1
62.5
heel bone mineral density
2
2
2
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
76.1
lymphocyte percentage of leukocytes
1
62.5
heel bone mineral density
2
57.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heparan sulfate 6-O-sulfotransferase 1
VGNC:10836
470530
Mouse
MGI:1354958
50785
Rat
RGD:1309218
316325
Horse
heparan sulfate 6-O-sulfotransferase 1
100068973
Cow
heparan sulfate 6-O-sulfotransferase 1
VGNC:29962
518563
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heparan sulfate 6-O-sulfotransferase 1
Mouse
Rat
Horse
heparan sulfate 6-O-sulfotransferase 1
Cow
heparan sulfate 6-O-sulfotransferase 1
Publication Statistics
PubMed Score 77.13
PubMed score by year
PubTator Score 33.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title