You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HS3ST4
Heparan sulfate glucosamine 3-O-sulfotransferase 4

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331351
  • ENSP00000330606
  • ENSG00000182601

Symbol
  • 3OST4
  • 30ST4
  • 3OST4
  • 3-OST-4
  • h3-OST-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
pathway
0.65
microRNA
0.64
cell line
0.62
cell type or tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.45   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 22   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.45   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
SDC2
Tbio
Novelty:  0.00597758
Score:  0.94
Data Source:  STRINGDB
GPC2
Tbio
Novelty:  0.02182363
Score:  0.925
Data Source:  STRINGDB
GPC6
Tbio
Novelty:  0.01951872
Score:  0.924
Data Source:  STRINGDB
GPC4
Tbio
Novelty:  0.01319626
Score:  0.924
Data Source:  STRINGDB
GPC5
Tbio
Novelty:  0.01257358
Score:  0.917
Data Source:  STRINGDB
GPC1
Tbio
Novelty:  0.00293087
Score:  0.916
Data Source:  STRINGDB
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.914
Data Source:  STRINGDB
SDC3
Tbio
Novelty:  0.01095269
Score:  0.913
Data Source:  STRINGDB
GPC3
Tbio
Novelty:  0.00151823
Score:  0.912
Data Source:  STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.907
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG biosynthesis
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
HS-GAG biosynthesis
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1333792
628779
Zebrafish
ZDB-GENE-070202-8
563570
Publication Statistics
PubMed Score 5.45
PubMed score by year
PubTator Score 3.53
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title