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Tbio
HS3ST3B1
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. The protein encoded by this gene is a type II integral membrane protein that belongs to the 3-O-sulfotransferases family. These proteins catalyze the addition of sulfate groups at the 3-OH position of glucosamine in heparan sulfate. The substrate specificity of individual members of the family is based on prior modification of the heparan sulfate chain, thus allowing different members of the family to generate binding sites for diffe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360954
  • ENSP00000354213
  • ENSG00000125430
  • ENST00000466596
  • ENSP00000436078

Symbol
  • 3OST3B1
  • HS3ST3B
  • 3OST3B1
  • 3-OST-3B
  • h3-OST-3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
PubMedID
0.73
histone modification site profile
0.67
gene perturbation
0.62
tissue sample
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.68   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.68   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
ATL3
Tbio
Novelty:  0.05295598
p_int:  0.99996092
p_ni:  0.00003908
Data Source:  BioPlex
ARHGAP40
Tdark
Family:  Enzyme
Novelty:  4.12645161
p_int:  0.949947796
p_ni:  1e-9
p_wrong:  0.050052203
Data Source:  BioPlex
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.886791255
p_ni:  7e-9
p_wrong:  0.113208739
Score:  0.187
Data Source:  BioPlex,STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
p_int:  0.873222434
p_ni:  0.126777566
Data Source:  BioPlex
ZER1
Tbio
Novelty:  0.02989698
p_int:  0.847785559
p_ni:  0.152214441
Data Source:  BioPlex
SDC2
Tbio
Novelty:  0.00597758
Score:  0.95
Data Source:  STRINGDB
GPC6
Tbio
Novelty:  0.01951872
Score:  0.934
Data Source:  STRINGDB
GPC3
Tbio
Novelty:  0.00151823
Score:  0.933
Data Source:  STRINGDB
GPC1
Tbio
Novelty:  0.00293087
Score:  0.926
Data Source:  STRINGDB
GPC2
Tbio
Novelty:  0.02182363
Score:  0.926
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG biosynthesis
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
HS-GAG biosynthesis
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
2
1
7
58.3
Myopia
1
1
0
7
13.7
age at onset
1
1
0
7
13.7
colorectal health
1
1
0
2
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
7
58.3
Myopia
0
7
13.7
age at onset
0
7
13.7
colorectal health
0
2
0.8
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heparan sulfate-glucosamine 3-sulfotransferase 3B1
VGNC:12288
468393
Mouse
MGI:1333853
54710
Rat
RGD:1307326
303218
Cow
heparan sulfate-glucosamine 3-sulfotransferase 3B1
617069
Anole lizard
heparan sulfate glucosamine 3-O-sulfotransferase 3B1-like
100555056
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heparan sulfate-glucosamine 3-sulfotransferase 3B1
Mouse
Rat
Cow
heparan sulfate-glucosamine 3-sulfotransferase 3B1
Anole lizard
heparan sulfate glucosamine 3-O-sulfotransferase 3B1-like
Publication Statistics
PubMed Score 13.68
PubMed score by year
PubTator Score 7.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title