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Tbio
HS3ST2
Heparan sulfate glucosamine 3-O-sulfotransferase 2

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261374
  • ENSP00000261374
  • ENSG00000122254

Symbol
  • 3OST2
  • 30ST2
  • 3OST2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.6
pathway
0.58
cell type or tissue
0.56
transcription factor binding site profile
0.56
gene perturbation
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.6   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.6   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
SCARA5
Tbio
Novelty:  0.01727557
p_int:  0.999990563
p_ni:  0.000009435
p_wrong:  1e-9
Score:  0.297
Data Source:  BioPlex,STRINGDB
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.999990545
p_ni:  0.000009455
Data Source:  BioPlex
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.99111927
p_ni:  0.00888073
Data Source:  BioPlex
MANEAL
Tdark
Family:  Enzyme
Novelty:  0.71535497
p_int:  0.969446899
p_ni:  0.030521847
p_wrong:  0.000031254
Score:  0.183
Data Source:  BioPlex,STRINGDB
PIGA
Tbio
Family:  Enzyme
Novelty:  0.00172769
p_int:  0.963656009
p_ni:  0.036343893
p_wrong:  9.8e-8
Data Source:  BioPlex
NRM
Tbio
Novelty:  0.02136368
p_int:  0.954920755
p_ni:  0.000034182
p_wrong:  0.045045063
Score:  0.219
Data Source:  BioPlex,STRINGDB
ATL3
Tbio
Novelty:  0.05295598
p_int:  0.950809984
p_ni:  0.049189922
p_wrong:  9.4e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
TMEM132A
Tdark
Novelty:  0.26489093
p_int:  0.843519448
p_ni:  0.156476447
p_wrong:  0.000004105
Data Source:  BioPlex
TMEM214
Tdark
Novelty:  0.32604613
p_int:  0.817810615
p_ni:  0.182189385
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.813401946
p_ni:  0.186598054
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Glycosaminoglycan metabolism (R-HSA-1630316)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG biosynthesis
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
HS-GAG biosynthesis
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heparan sulfate-glucosamine 3-sulfotransferase 2
VGNC:5795
467924
Mouse
MGI:1333802
195646
Rat
RGD:727787
293451
Dog
heparan sulfate-glucosamine 3-sulfotransferase 2
VGNC:41792
489975
Horse
heparan sulfate-glucosamine 3-sulfotransferase 2
VGNC:18875
100068342
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heparan sulfate-glucosamine 3-sulfotransferase 2
Mouse
Rat
Dog
heparan sulfate-glucosamine 3-sulfotransferase 2
Horse
heparan sulfate-glucosamine 3-sulfotransferase 2
Publication Statistics
PubMed Score 20.60
PubMed score by year
PubTator Score 19.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title