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Tbio
HS1BP3
HCLS1-binding protein 3

Protein Summary
Description
May be a modulator of IL-2 signaling. The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1/Hs1-interacting protein that may be involved in lymphocyte activation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304031
  • ENSP00000305193
  • ENSG00000118960

Symbol
  • ETM2
  • HS1-BP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor perturbation
0.8
transcription factor binding site profile
0.75
kinase perturbation
0.71
transcription factor
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.87   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.87   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999984598
p_ni:  5.9e-8
p_wrong:  0.000015344
Score:  0.394
Data Source:  BioPlex,STRINGDB
PDXDC1
Tbio
Family:  Enzyme
Novelty:  0.16529476
p_int:  0.999812134
p_ni:  0.000187866
Score:  0.169
Data Source:  BioPlex,STRINGDB
TMED3
Tbio
Novelty:  0.06696993
p_int:  0.992035116
p_ni:  0.007964883
p_wrong:  1e-9
Score:  0.28
Data Source:  BioPlex,STRINGDB
RAD50
Tbio
Novelty:  0.02161298
p_int:  0.938979016
p_ni:  0.061020984
Score:  0.188
Data Source:  BioPlex,STRINGDB
ANTXR2
Tchem
Novelty:  0.00632874
p_int:  0.937558498
p_ni:  0.062441411
p_wrong:  9.1e-8
Score:  0.309
Data Source:  BioPlex,STRINGDB
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.794477199
p_ni:  0.205522791
p_wrong:  1e-8
Data Source:  BioPlex
LDAH
Tbio
Family:  Enzyme
Novelty:  0.0951829
Score:  0.812
Data Source:  STRINGDB
HCLS1
Tbio
Novelty:  0.08304056
Score:  0.763
Data Source:  STRINGDB
TBC1D14
Tbio
Novelty:  0.25089884
Score:  0.718
Data Source:  STRINGDB
DRD3
Tclin
Family:  GPCR
Novelty:  0.00230028
Score:  0.717
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
4
4
94.6
digit length ratio
3
1
4
89.7
apolipoprotein B measurement
1
4
4
88.5
total cholesterol measurement
2
4
4
87.5
2
2
1
1.1
86.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
94.6
digit length ratio
4
89.7
apolipoprotein B measurement
4
88.5
total cholesterol measurement
4
87.5
1
1.1
86.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HCLS1 binding protein 3
VGNC:10685
470321
Macaque
HCLS1 binding protein 3 [Source:HGNC Symbol;Acc:HGNC:24979]
Mouse
MGI:1913224
58240
Rat
RGD:1311331
313950
Dog
HCLS1 binding protein 3
VGNC:41790
610655
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HCLS1 binding protein 3
Macaque
HCLS1 binding protein 3 [Source:HGNC Symbol;Acc:HGNC:24979]
Mouse
Rat
Dog
HCLS1 binding protein 3
Publication Statistics
PubMed Score 12.87
PubMed score by year
PubTator Score 7.82
PubTator score by year
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Related Publications
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PMID
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