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Tclin
HRH3
Histamine H3 receptor

Protein Summary
Description
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization. Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340177
  • ENSP00000342560
  • ENSG00000101180

Symbol
  • GPCR97
  • HH3R
  • GPCR97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.98
biological process
0.95
disease perturbation
0.74
chemical
0.64
molecular function
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 678.34   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 434   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 678.34   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 434   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3031
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (292)
MCHR2
Tchem
Family:  GPCR
Novelty:  0.01191922
Score:  0.953
Data Source:  STRINGDB
GRM4
Tchem
Family:  GPCR
Novelty:  0.00380434
Score:  0.949
Data Source:  STRINGDB
HTR5A
Tchem
Family:  GPCR
Novelty:  0.0160551
Score:  0.947
Data Source:  STRINGDB
GRM3
Tchem
Family:  GPCR
Novelty:  0.00340947
Score:  0.945
Data Source:  STRINGDB
GNG3
Tbio
Novelty:  0.16941216
Score:  0.941
Data Source:  STRINGDB
GNG13
Tbio
Novelty:  0.13011919
Score:  0.94
Data Source:  STRINGDB
PDYN
Tbio
Novelty:  0.00039564
Score:  0.938
Data Source:  STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.938
Data Source:  STRINGDB
HTR1E
Tchem
Family:  GPCR
Novelty:  0.02160816
Score:  0.937
Data Source:  STRINGDB
GRM8
Tchem
Family:  GPCR
Novelty:  0.00827879
Score:  0.936
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
71.2
alkaline phosphatase measurement
2
2
1
6
69.6
glomerular filtration rate
2
2
2
69.1
reticulocyte count
2
1
2
68.6
mean platelet volume
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
71.2
alkaline phosphatase measurement
1
6
69.6
glomerular filtration rate
2
69.1
reticulocyte count
2
68.6
mean platelet volume
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histamine receptor H3
VGNC:14229
458385
Macaque
histamine receptor H3
574253
Mouse
MGI:2139279
99296
Rat
RGD:620630
85268
Dog
histamine receptor H3
VGNC:54313
477282
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histamine receptor H3
Macaque
histamine receptor H3
Mouse
Rat
Dog
histamine receptor H3
Publication Statistics
PubMed Score 678.34
PubMed score by year
PubTator Score 344.49
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title