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Tbio
HRG
Histidine-rich glycoprotein

Protein Summary
Description
Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232003
  • ENSP00000232003
  • ENSG00000113905

Symbol
  • HPRG
  • HRGP
  • THPH11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.96
cellular component
0.85
biological term
0.53
tissue
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.26   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.26   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (187)
FBN1
Tbio
Novelty:  0.00074957
p_int:  0.999995448
p_ni:  0.000001682
p_wrong:  0.00000287
Data Source:  BioPlex
LTBP4
Tbio
Novelty:  0.02008164
p_int:  0.999896217
p_ni:  0.000103783
Data Source:  BioPlex
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.999710164
p_ni:  0.000289829
p_wrong:  7e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999330858
p_ni:  0.000127423
p_wrong:  0.000541719
Data Source:  BioPlex
P3H3
Tbio
Family:  Enzyme
Novelty:  0.0010004
p_int:  0.999324356
p_ni:  0.000675644
Data Source:  BioPlex
FBLN5
Tbio
Novelty:  0.00599598
p_int:  0.998747991
p_ni:  0.001250379
p_wrong:  0.00000163
Data Source:  BioPlex
CRTAP
Tbio
Novelty:  0.02380647
p_int:  0.997581792
p_ni:  0.002418209
Data Source:  BioPlex
PLSCR1
Tbio
Family:  Enzyme
Novelty:  0.01483138
p_int:  0.991188048
p_ni:  0.007756462
p_wrong:  0.00105549
Data Source:  BioPlex
P3H1
Tbio
Family:  Enzyme
Novelty:  0.02067711
p_int:  0.987332824
p_ni:  0.012667176
Data Source:  BioPlex
MED30
Tbio
Family:  Enzyme
Novelty:  0.08618054
p_int:  0.985469443
p_ni:  0.012581787
p_wrong:  0.00194877
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Dissolution of Fibrin Clot (R-HSA-75205)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Dissolution of Fibrin Clot
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Dissolution of Fibrin Clot
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (47)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
partial thromboplastin time
2
3
3
95.7
glomerular filtration rate
7
5
6
8.1
92
factor XI measurement
1
1
1
88.4
TNF-related apoptosis-inducing ligand measurement
1
1
1
84.9
calcium measurement
1
3
3
77.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
partial thromboplastin time
3
95.7
glomerular filtration rate
6
8.1
92
factor XI measurement
1
88.4
TNF-related apoptosis-inducing ligand measurement
1
84.9
calcium measurement
3
77.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histidine rich glycoprotein
VGNC:7068
460914
Macaque
histidine rich glycoprotein
699100
Mouse
MGI:2146636
94175
Rat
RGD:619808
171016
Dog
histidine rich glycoprotein
VGNC:41785
100683193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histidine rich glycoprotein
Macaque
histidine rich glycoprotein
Mouse
Rat
Dog
histidine rich glycoprotein
Publication Statistics
PubMed Score 413.26
PubMed score by year
PubTator Score 174.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title