Tbio HRC Sarcoplasmic reticulum histidine-rich calcium-binding protein

Protein Summary

Description

May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• P23327
• Q504Y6

Gene Name

• HRC

Ensembl ID

• ENST00000252825
• ENSP00000252825
• ENSG00000130528

Symbol

• HCP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.71
cell type or tissue	0.68
cellular component	0.61
PubMedID	0.6
tissue sample	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.62   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.62   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0