Tbio HRASLS Phospholipid-metabolizing enzyme A-C1

Protein Summary

Description

Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs.

Uniprot Accession IDs

• Q9HDD0
• D2KX19

Gene Name

• HRASLS

Ensembl ID

• ENST00000602513
• ENSP00000473258
• ENSG00000127252

Symbol

• A-C1
• HRSL1
• HSD28
• HRASLS
• HRASLS1
• PLA/AT1
• PLAAT-1
• H-REV107

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.81
PubMedID	0.76
gene perturbation	0.65
virus perturbation	0.64
histone modification site profile	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.42   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.42   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0