Tbio HR Lysine-specific demethylase hairless

Protein Summary

Description

Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• O43593
• Q6GS30
• Q96H33
• Q9NPE1

Gene Name

• HR

Ensembl ID

• ENST00000312841
• ENSP00000326765
• ENSG00000168453
• ENST00000381418
• ENSP00000370826

Symbol

• AU
• MUHH
• ALUNC
• HYPT4
• MUHH1
• HSA277165

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.66
cell type or tissue	0.6
molecular function	0.6
phenotype	0.57
disease perturbation	0.56

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Lysine-specific Demethylase Hairless

Protein / Nucleic Acid Binding / Lysine-specific Demethylase Hairless

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Lysine-specific Demethylase Hairless

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.76   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.76   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0