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Tbio
HPX
Hemopexin

Protein Summary
Description
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265983
  • ENSP00000265983
  • ENSG00000110169

Symbol
  • HX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
gene perturbation
0.83
cell type or tissue
0.69
cell line
0.64
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 696.84   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 520   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 696.84   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 520   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999986858
p_ni:  0.000013065
p_wrong:  7.7e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.999934391
p_ni:  0.000017198
p_wrong:  0.000048411
Score:  0.2
Data Source:  BioPlex,STRINGDB
GALNT12
Tbio
Family:  Enzyme
Novelty:  0.085131
p_int:  0.997271471
p_ni:  0.002728509
p_wrong:  1.9e-8
Score:  0.304
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.988788579
p_ni:  0.000168584
p_wrong:  0.011042838
Score:  0.185
Data Source:  BioPlex,STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.976
Data Source:  Reactome,STRINGDB
LRP1
Tbio
Novelty:  0.00200788
Score:  0.965
Data Source:  Reactome,STRINGDB
HBB
Tbio
Novelty:  0.00049683
Score:  0.937
Data Source:  Reactome,STRINGDB
HP
Tbio
Novelty:  0.00016649
Score:  0.898
Data Source:  STRINGDB
FGG
Tbio
Novelty:  0.00404457
Score:  0.881
Data Source:  STRINGDB
GC
Tchem
Novelty:  0.00065382
Score:  0.835
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Scavenging of heme from plasma
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Scavenging of heme from plasma
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hemopexin
VGNC:1061
450992
Macaque
hemopexin
711007
Mouse
MGI:105112
15458
Rat
RGD:62040
58917
Dog
hemopexin
VGNC:41780
610982
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hemopexin
Macaque
hemopexin
Mouse
Rat
Dog
hemopexin
Publication Statistics
PubMed Score 696.84
PubMed score by year
PubTator Score 394.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title