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Tbio
HPSE2
Inactive heparanase-2

Protein Summary
Description
Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370546
  • ENSP00000359577
  • ENSG00000172987
  • ENST00000370549
  • ENSP00000359580
  • ENST00000370552
  • ENSP00000359583
  • ENST00000628193
  • ENSP00000485916

Symbol
  • HPA2
  • UFS
  • HPA2
  • HPR2
  • UFS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.7
pathway
0.68
disease
0.61
trait
0.61
transcription factor
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.22   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.22   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.999997147
p_ni:  0.000002853
Data Source:  BioPlex
ANKRD17
Tbio
Novelty:  0.03177323
p_int:  0.999396807
p_ni:  0.000603193
Data Source:  BioPlex
DCAF1
Tbio
Novelty:  0.0170232
p_int:  0.998460554
p_ni:  0.001539446
Data Source:  BioPlex
PEX6
Tbio
Family:  Enzyme
Novelty:  0.00874708
p_int:  0.997835226
p_ni:  0.002128291
p_wrong:  0.000036482
Data Source:  BioPlex
TIMM10B
Tdark
Family:  Enzyme
Novelty:  0.36798313
p_int:  0.99655752
p_ni:  0.003436323
p_wrong:  0.000006158
Data Source:  BioPlex
TARBP2
Tbio
Novelty:  0.01485994
p_int:  0.993215377
p_ni:  0.006784622
p_wrong:  1e-9
Data Source:  BioPlex
RNF13
Tbio
Family:  Enzyme
Novelty:  0.09764564
p_int:  0.992601695
p_ni:  0.004843304
p_wrong:  0.002555002
Data Source:  BioPlex
NAF1
Tbio
Novelty:  2.99493689
p_int:  0.991558777
p_ni:  0.002884345
p_wrong:  0.005556878
Data Source:  BioPlex
PPP1R15B
Tchem
Family:  Enzyme
Novelty:  0.0244819
p_int:  0.990264333
p_ni:  0.006983879
p_wrong:  0.002751789
Data Source:  BioPlex
CENPB
Tbio
Novelty:  0.0036225
p_int:  0.984725325
p_ni:  0.015274674
p_wrong:  1e-9
Data Source:  BioPlex
Pathways (8)
Glycosaminoglycan metabolism (R-HSA-1630316)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG degradation
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
HS-GAG degradation
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
2
4
10
98.9
metabolite measurement
2
2
1
1.2
95.8
blood metabolite measurement
1
1
2
88.7
serum metabolite measurement
1
1
2
88.4
trimethylamine measurement
1
1
0
1
87.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
10
98.9
metabolite measurement
1
1.2
95.8
blood metabolite measurement
2
88.7
serum metabolite measurement
2
88.4
trimethylamine measurement
0
1
87.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heparanase 2 (inactive)
VGNC:49017
466176
Macaque
heparanase 2 (inactive)
708795
Mouse
MGI:2685814
545291
Dog
heparanase 2 (inactive)
486831
Horse
heparanase 2 (inactive) [Source:HGNC Symbol;Acc:HGNC:18374]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heparanase 2 (inactive)
Macaque
heparanase 2 (inactive)
Mouse
Dog
heparanase 2 (inactive)
Horse
heparanase 2 (inactive) [Source:HGNC Symbol;Acc:HGNC:18374]
Publication Statistics
PubMed Score 186.22
PubMed score by year
PubTator Score 90.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title