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Tchem
HPSE
Heparanase

Protein Summary
Description
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation fa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311412
  • ENSP00000308107
  • ENSG00000173083
  • ENST00000405413
  • ENSP00000384262
  • ENST00000509906
  • ENSP00000421038
  • ENST00000512196
  • ENSP00000423265
  • ENST00000513463
  • ENSP00000421365

Symbol
  • HEP
  • HPA
  • HPA1
  • HPR1
  • HPSE1
  • HSE1
  • HPA
  • HPA1
  • HPR1
  • HSE1
  • HPSE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor perturbation
0.74
interacting protein
0.73
biological process
0.72
cellular component
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.64   (req: < 5)
Gene RIFs: 275   (req: <= 3)
Antibodies: 512   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.64   (req: >= 5)
Gene RIFs: 275   (req: > 3)
Antibodies: 512   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 125
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (126)
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.99748541
p_ni:  0.002330151
p_wrong:  0.000184438
Data Source:  BioPlex
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.997231801
p_ni:  0.002768176
p_wrong:  2.4e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
DNAJA4
Tbio
Novelty:  0.15880924
p_int:  0.994876838
p_ni:  0.005123126
p_wrong:  3.6e-8
Score:  0.408
Data Source:  BioPlex,STRINGDB
OS9
Tbio
Novelty:  0.01490339
p_int:  0.9526299
p_ni:  0.032104919
p_wrong:  0.015265181
Score:  0.179
Data Source:  BioPlex,STRINGDB
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.803670325
p_ni:  0.122146409
p_wrong:  0.074183266
Data Source:  BioPlex
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.953
Data Source:  STRINGDB
SDC1
Tbio
Novelty:  0.00044792
Score:  0.951
Data Source:  STRINGDB
GPC1
Tbio
Novelty:  0.00293087
Score:  0.938
Data Source:  STRINGDB
SDC2
Tbio
Novelty:  0.00597758
Score:  0.928
Data Source:  STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.925
Data Source:  STRINGDB
Pathways (12)
Glycosaminoglycan metabolism (R-HSA-1630316)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG degradation
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
HS-GAG degradation
Heparan sulfate/heparin (HS-GAG) metabolism
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
7
4
7
96.2
leukocyte count
2
2
2
82
estradiol measurement
3
1
2
7.1
58.5
monocyte percentage of leukocytes
1
1
1
22.5
granulocyte percentage of myeloid white cells
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
7
96.2
leukocyte count
2
82
estradiol measurement
2
7.1
58.5
monocyte percentage of leukocytes
1
22.5
granulocyte percentage of myeloid white cells
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heparanase
VGNC:614
461206
Macaque
heparanase
707583
Mouse
MGI:1343124
15442
Rat
RGD:61969
64537
Dog
heparanase
VGNC:41779
608707
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heparanase
Macaque
heparanase
Mouse
Rat
Dog
heparanase
Publication Statistics
PubMed Score 783.64
PubMed score by year
PubTator Score 582.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title