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Tchem
HPGD
15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Protein Summary
Description
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells. This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296521
  • ENSP00000296521
  • ENSG00000164120
  • ENST00000296522
  • ENSP00000296522
  • ENST00000422112
  • ENSP00000398720
  • ENST00000510901
  • ENSP00000422418
  • ENST00000541923
  • ENSP00000438017
  • ENST00000542498
  • ENSP00000443644

Symbol
  • PGDH1
  • SDR36C1
  • PGDH
  • PGDH1
  • PHOAR1
  • 15-PGDH
  • SDR36C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
molecular function
0.95
transcription factor perturbation
0.91
PubMedID
0.9
small molecule perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.68   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 469   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.68   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 469   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 211
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0