Tclin HPD 4-hydroxyphenylpyruvate dioxygenase

Protein Summary

Description

Key enzyme in the degradation of tyrosine. The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• P32754
• A8K461
• B3KQ63
• Q13234

Gene Name

• HPD

Ensembl ID

• ENST00000543163
• ENSP00000441677
• ENSG00000158104

Symbol

• PPD
• PPD
• 4HPPD
• GLOD3
• 4-HPPD
• HPPDASE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
disease perturbation	0.87
transcription factor binding site profile	0.72
cellular component	0.61
tissue	0.58

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / 4-hydroxyphenylpyruvate Dioxygenase

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / 4-hydroxyphenylpyruvate Dioxygenase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.31   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 302   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.31   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 109

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1