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Tclin
HPD
4-hydroxyphenylpyruvate dioxygenase

Protein Summary
Description
Key enzyme in the degradation of tyrosine. The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000543163
  • ENSP00000441677
  • ENSG00000158104

Symbol
  • PPD
  • PPD
  • 4HPPD
  • GLOD3
  • 4-HPPD
  • HPPDASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
disease perturbation
0.87
transcription factor binding site profile
0.72
cellular component
0.61
tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.31   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.31   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 109
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1