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Tbio
HPCAL1
Hippocalcin-like protein 1

Protein Summary
Description
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307845
  • ENSP00000310749
  • ENSG00000115756
  • ENST00000381765
  • ENSP00000371184
  • ENST00000613496
  • ENSP00000478231
  • ENST00000620771
  • ENSP00000483786
  • ENST00000622018
  • ENSP00000482993

Symbol
  • BDR1
  • BDR1
  • HLP2
  • VILIP-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
disease perturbation
0.9
transcription factor binding site profile
0.84
kinase perturbation
0.76
transcription factor
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.02   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.02   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.999980539
p_ni:  0.000019349
p_wrong:  1.11e-7
Data Source:  BioPlex
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.999462894
p_ni:  0.000535679
p_wrong:  0.000001427
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.999293536
p_ni:  0.000706434
p_wrong:  3e-8
Data Source:  BioPlex
ACBD7
Tdark
Novelty:  0.32019061
p_int:  0.998832997
p_ni:  0.001165664
p_wrong:  0.000001339
Score:  0.169
Data Source:  BioPlex,STRINGDB
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.998003165
p_ni:  0.001996561
p_wrong:  2.74e-7
Data Source:  BioPlex
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.997366099
p_ni:  0.002630994
p_wrong:  0.000002907
Data Source:  BioPlex
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.996912798
p_ni:  0.003080024
p_wrong:  0.000007178
Data Source:  BioPlex
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.996901436
p_ni:  0.003048376
p_wrong:  0.000050188
Data Source:  BioPlex
S1PR2
Tchem
Family:  GPCR
Novelty:  0.00372765
p_int:  0.995221222
p_ni:  0.004752144
p_wrong:  0.000026634
Data Source:  BioPlex
MGLL
Tchem
Family:  Enzyme
Novelty:  0.00196912
p_int:  0.994023609
p_ni:  0.005884595
p_wrong:  0.000091797
Score:  0.312
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
10.6
mathematical ability
2
1
2
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
10.6
mathematical ability
2
1.1
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hippocalcin like 1
VGNC:6392
459026
Macaque
hippocalcin like 1
695395
Mouse
MGI:1855689
53602
Rat
RGD:708375
50871
Dog
hippocalcin like 1
VGNC:41768
609787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hippocalcin like 1
Macaque
hippocalcin like 1
Mouse
Rat
Dog
hippocalcin like 1
Publication Statistics
PubMed Score 25.02
PubMed score by year
PubTator Score 20.26
PubTator score by year
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Related Publications
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PMID
Year
Title