Tbio HPCA Neuron-specific calcium-binding protein hippocalcin

Protein Summary

Description

Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity). The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P84074
• B2R9T3
• D3DPQ7
• P32076
• P41211
• P70510

Gene Name

• HPCA

Ensembl ID

• ENST00000373467
• ENSP00000362566
• ENSG00000121905

Symbol

• BDR2
• BDR2
• DYT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.66
cell type or tissue	0.65
protein domain	0.58
PubMedID	0.55
transcription factor binding site profile	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.58   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.58   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0