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Tbio
HPCA
Neuron-specific calcium-binding protein hippocalcin

Protein Summary
Description
Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity). The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373467
  • ENSP00000362566
  • ENSG00000121905

Symbol
  • BDR2
  • BDR2
  • DYT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.66
cell type or tissue
0.65
protein domain
0.58
PubMedID
0.55
transcription factor binding site profile
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.25   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.25   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999999371
p_ni:  5.69e-7
p_wrong:  6e-8
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.999995701
p_ni:  0.000002298
p_wrong:  0.000002001
Data Source:  BioPlex
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.999980359
p_ni:  0.00001964
p_wrong:  1e-9
Data Source:  BioPlex
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999867716
p_ni:  7.47e-7
p_wrong:  0.000131537
Data Source:  BioPlex
GRK1
Tchem
Family:  Kinase
Novelty:  0.00598725
Score:  0.863
Data Source:  STRINGDB
NAIP
Tbio
Novelty:  0.00400896
Score:  0.794
Data Source:  STRINGDB
KCND3
Tclin
Family:  IC
Novelty:  0.00328276
Score:  0.786
Data Source:  STRINGDB
KCNC1
Tclin
Family:  IC
Novelty:  0.00252943
Score:  0.785
Data Source:  STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
Score:  0.734
Data Source:  STRINGDB
TUBB4A
Tclin
Novelty:  0.00045092
Score:  0.715
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1
1
15.7
mosaic loss of chromosome Y measurement
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
15.7
mosaic loss of chromosome Y measurement
1
3.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hippocalcin
VGNC:1264
746988
Macaque
hippocalcin
710249
Mouse
MGI:1336200
15444
Rat
RGD:620060
29177
Dog
hippocalcin
VGNC:52136
611787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hippocalcin
Macaque
hippocalcin
Mouse
Rat
Dog
hippocalcin
Publication Statistics
PubMed Score 80.25
PubMed score by year
PubTator Score 23.25
PubTator score by year
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Related Publications
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PMID
Year
Title