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Tbio
HP1BP3
Heterochromatin protein 1-binding protein 3

Protein Summary
Description
Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312239
  • ENSP00000312625
  • ENSG00000127483
  • ENST00000375000
  • ENSP00000364139
  • ENST00000375003
  • ENSP00000364142

Symbol
  • HP1BP74
  • HP1-BP74
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.99
drug perturbation
0.96
virus perturbation
0.95
small molecule perturbation
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.12   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.12   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
IPO7
Tbio
Novelty:  0.01319011
p_int:  0.997781128
p_ni:  0.002218872
Score:  0.165
Data Source:  BioPlex,STRINGDB
DDI2
Tbio
Novelty:  0.09288646
p_int:  0.948427884
p_ni:  0.051572116
Score:  0.189
Data Source:  BioPlex,STRINGDB
NUSAP1
Tbio
Novelty:  0.01702118
p_int:  0.93058778
p_ni:  0.06941222
Score:  0.315
Data Source:  BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.89910919
p_ni:  0.10089081
Data Source:  BioPlex
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.896645024
p_ni:  0.103354976
Data Source:  BioPlex
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.882717619
p_ni:  0.117282381
Data Source:  BioPlex
IPO8
Tbio
Novelty:  0.00934966
p_int:  0.870926819
p_ni:  0.129073181
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.854559512
p_ni:  0.145440488
Data Source:  BioPlex
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.845139531
p_ni:  0.154860469
Data Source:  BioPlex
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.842752109
p_ni:  0.157247891
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
88.3
chronotype measurement
2
3
1
1
87
eosinophil count
2
2
2
57.1
wellbeing measurement
2
2
2
57.1
risk-taking behaviour
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
88.3
chronotype measurement
1
1
87
eosinophil count
2
57.1
wellbeing measurement
2
57.1
risk-taking behaviour
1
56.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heterochromatin protein 1 binding protein 3
VGNC:8051
456593
Macaque
heterochromatin protein 1 binding protein 3
706362
Mouse
MGI:109369
15441
Rat
RGD:735099
313647
Dog
heterochromatin protein 1 binding protein 3
VGNC:41767
478203
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heterochromatin protein 1 binding protein 3
Macaque
heterochromatin protein 1 binding protein 3
Mouse
Rat
Dog
heterochromatin protein 1 binding protein 3
Publication Statistics
PubMed Score 18.12
PubMed score by year
PubTator Score 7.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title