You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HOXC9
Homeobox protein Hox-C9

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303450
  • ENSP00000302836
  • ENSG00000180806
  • ENST00000508190
  • ENSP00000423861

Symbol
  • HOX3B
  • HOX3
  • HOX3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.83
PubMedID
0.69
transcription factor
0.61
transcription factor binding site profile
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.43   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.43   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.999999965
p_ni:  3.5e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.999999741
p_ni:  2.58e-7
p_wrong:  1e-9
Data Source:  BioPlex
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.999987332
p_ni:  0.000012652
p_wrong:  1.5e-8
Data Source:  BioPlex
PIGT
Tbio
Family:  Enzyme
Novelty:  0.02539879
p_int:  0.999868407
p_ni:  0.000128752
p_wrong:  0.00000284
Score:  0.185
Data Source:  BioPlex,STRINGDB
IDE
Tchem
Family:  Enzyme
Novelty:  0.00207793
p_int:  0.997698709
p_ni:  0.002301291
Score:  0.534
Data Source:  BioPlex,STRINGDB
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.992974499
p_ni:  0.00312108
p_wrong:  0.003904422
Score:  0.535
Data Source:  BioPlex,STRINGDB
NDUFS1
Tclin
Family:  Enzyme
Novelty:  0.0215624
p_int:  0.816806746
p_ni:  0.183193254
Score:  0.187
Data Source:  BioPlex,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.75921932
p_ni:  0.000156937
p_wrong:  0.240623742
Data Source:  BioPlex
HOXC4
Tbio
Family:  TF
Novelty:  0.02206351
Score:  0.9
Data Source:  STRINGDB
HOXC5
Tbio
Family:  TF
Novelty:  0.05354226
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
20
55
98.5
waist circumference
2
16
16
97.7
waist-hip ratio
7
18
22
97.6
BMI-adjusted waist circumference
7
15
26
97.3
platelet crit
1
2
2
85.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
55
98.5
waist circumference
16
97.7
waist-hip ratio
22
97.6
BMI-adjusted waist circumference
26
97.3
platelet crit
2
85.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox C9
VGNC:5421
735639
Mouse
MGI:96199
15427
Horse
homeobox C9
VGNC:18851
100629421
Cow
homeobox C9
VGNC:29928
100295214
Xenopus
homeobox C9
XB-GENE-482330
550010
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox C9
Mouse
Horse
homeobox C9
Cow
homeobox C9
Xenopus
homeobox C9
Publication Statistics
PubMed Score 38.43
PubMed score by year
PubTator Score 19.36
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title