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Tbio
HOXC10
Homeobox protein Hox-C10

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303460
  • ENSP00000307321
  • ENSG00000180818

Symbol
  • HOX3I
  • HOX3I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
gene perturbation
0.85
transcription factor binding site profile
0.8
transcription factor
0.77
PubMedID
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.34   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 369   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.34   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
SNX15
Tdark
Novelty:  0.27466573
p_int:  0.999999801
p_ni:  1.99e-7
p_wrong:  1e-9
Score:  0.54
Data Source:  BioPlex,STRINGDB
TRMU
Tbio
Family:  Enzyme
Novelty:  0.01615197
p_int:  0.999885982
p_ni:  0.000045949
p_wrong:  0.000068069
Score:  0.309
Data Source:  BioPlex,STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.996999678
p_ni:  0.003000322
Data Source:  BioPlex
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
p_int:  0.970725919
p_ni:  0.029230915
p_wrong:  0.000043167
Score:  0.188
Data Source:  BioPlex,STRINGDB
TBX4
Tbio
Family:  TF
Novelty:  0.01370005
Score:  0.814
Data Source:  STRINGDB
TBX5
Tbio
Family:  TF
Novelty:  0.00272208
Score:  0.672
Data Source:  STRINGDB
HOXC11
Tbio
Family:  TF
Novelty:  0.03595579
Score:  0.643
Data Source:  STRINGDB
HOXC8
Tbio
Family:  TF
Novelty:  0.01042291
Score:  0.615
Data Source:  STRINGDB
TBX3
Tbio
Family:  TF
Novelty:  0.00515507
Score:  0.578
Data Source:  STRINGDB
TBX6
Tbio
Family:  TF
Novelty:  0.01060902
Score:  0.575
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
20
55
98.5
waist circumference
2
16
16
97.7
waist-hip ratio
7
18
22
97.6
BMI-adjusted waist circumference
7
15
26
97.3
spine bone size
1
1
1
82.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
55
98.5
waist circumference
16
97.7
waist-hip ratio
22
97.6
BMI-adjusted waist circumference
26
97.3
spine bone size
1
82.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox C10
VGNC:5417
451947
Macaque
homeobox C10
702321
Mouse
MGI:96192
209448
Rat
RGD:1307250
315338
Dog
homeobox C10
VGNC:41756
486500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox C10
Macaque
homeobox C10
Mouse
Rat
Dog
homeobox C10
Publication Statistics
PubMed Score 48.34
PubMed score by year
PubTator Score 874.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title