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Tbio
HOXB5
Homeobox protein Hox-B5

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239151
  • ENSP00000239151
  • ENSG00000120075

Symbol
  • HOX2A
  • HOX2
  • HU-1
  • HOX2A
  • Hox2.1
  • HHO.C10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
disease perturbation
0.96
gene perturbation
0.91
protein domain
0.85
molecular function
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.72   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.72   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
HOXC4
Tbio
Family:  TF
Novelty:  0.02206351
p_int:  0.999978194
p_ni:  4e-9
p_wrong:  0.000021802
Score:  0.973
Data Source:  BioPlex,STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
p_int:  0.999934409
p_ni:  0.000065591
Score:  0.204
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.999703111
p_ni:  0.000296889
Score:  0.152
Data Source:  BioPlex,STRINGDB
CCNYL1
Tdark
Novelty:  0.45350824
p_int:  0.999422328
p_ni:  0.00057742
p_wrong:  2.52e-7
Data Source:  BioPlex
HIST1H1D
Tbio
Novelty:  0.00922175
p_int:  0.998744979
p_ni:  0.001255021
Score:  0.229
Data Source:  BioPlex,STRINGDB
CCNY
Tbio
Novelty:  0.01400663
p_int:  0.998721977
p_ni:  0.001273721
p_wrong:  0.000004302
Score:  0.221
Data Source:  BioPlex,STRINGDB
CTNNBL1
Tbio
Novelty:  0.0189038
p_int:  0.998641051
p_ni:  0.001284175
p_wrong:  0.000074775
Data Source:  BioPlex
SIRT5
Tchem
Family:  Epigenetic
Novelty:  0.00225239
p_int:  0.998544299
p_ni:  0.001455699
p_wrong:  2e-9
Score:  0.178
Data Source:  BioPlex,STRINGDB
ERICH5
Tdark
Novelty:  5.57504212
p_int:  0.988663685
p_ni:  0.01133267
p_wrong:  0.000003645
Data Source:  BioPlex
OCC1
Tbio
Novelty:  0.05175429
p_int:  0.987479434
p_ni:  0.005847878
p_wrong:  0.006672688
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
4
4
79
grip strength measurement
1
1
1
67.3
1
1
1
67
1
1
0
1.1
57
hemoglobin measurement
1
1
1
51.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
79
grip strength measurement
1
67.3
1
67
0
1.1
57
hemoglobin measurement
1
51.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox B5
VGNC:12283
749212
Mouse
MGI:96186
15413
Rat
RGD:1562292
497987
Dog
homeobox B5
100686000
Horse
homeobox B5
VGNC:49465
100055656
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox B5
Mouse
Rat
Dog
homeobox B5
Horse
homeobox B5
Publication Statistics
PubMed Score 105.72
PubMed score by year
PubTator Score 52.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title