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Tbio
HOXB1
Homeobox protein Hox-B1

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239174
  • ENSP00000355140
  • ENSG00000120094
  • ENST00000577092
  • ENSP00000459066
  • ENST00000644632
  • ENSP00000494703

Symbol
  • HOX2I
  • HOX2
  • HCFP3
  • HOX2I
  • Hox-2.9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
gene perturbation
0.7
biological process
0.66
PubMedID
0.63
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.07   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.07   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
PBX1
Tbio
Family:  TF
Novelty:  0.00329442
Score:  0.994
Data Source:  Reactome,STRINGDB
EGR2
Tbio
Family:  TF
Novelty:  0.00215433
Score:  0.977
Data Source:  STRINGDB
PKNOX1
Tbio
Family:  TF
Novelty:  0.01063674
Score:  0.967
Data Source:  Reactome,STRINGDB
MAFB
Tbio
Family:  TF
Novelty:  0.00646074
Score:  0.967
Data Source:  STRINGDB
MEIS1
Tbio
Family:  TF
Novelty:  0.00480433
Score:  0.96
Data Source:  Reactome,STRINGDB
KDM6A
Tchem
Family:  Epigenetic
Novelty:  0.00267001
Score:  0.953
Data Source:  STRINGDB
KMT2D
Tbio
Family:  Epigenetic
Novelty:  0.00380525
Score:  0.952
Data Source:  STRINGDB
SUZ12
Tbio
Novelty:  0.00402353
Score:  0.931
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.93
Data Source:  STRINGDB
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
61.4
grip strength measurement
1
1
1
53.3
1
1
1
46.5
comparative body size at age 10, self-reported
1
1
1
45.7
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
61.4
grip strength measurement
1
53.3
1
46.5
comparative body size at age 10, self-reported
1
45.7
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox B1
VGNC:9324
749225
Macaque
homeobox B1
696111
Mouse
MGI:96182
15407
Rat
RGD:1310298
303491
Dog
homeobox B1
VGNC:41749
491052
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox B1
Macaque
homeobox B1
Mouse
Rat
Dog
homeobox B1
Publication Statistics
PubMed Score 135.07
PubMed score by year
PubTator Score 50.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title