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Tbio
HOXA5
Homeobox protein Hox-A5

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222726
  • ENSP00000222726
  • ENSG00000106004

Symbol
  • HOX1C
  • HOX1
  • HOX1C
  • HOX1.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
biological process
0.96
protein domain
0.85
transcription factor perturbation
0.8
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.45   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 422   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.45   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 422   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.999992012
p_ni:  0.000007986
p_wrong:  2e-9
Data Source:  BioPlex
ERP44
Tbio
Novelty:  0.02352693
p_int:  0.941159767
p_ni:  0.058840233
Score:  0.325
Data Source:  BioPlex,STRINGDB
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.821920993
p_ni:  0.15188215
p_wrong:  0.026196857
Data Source:  BioPlex
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
Score:  0.977
Data Source:  STRINGDB
HOXA6
Tbio
Family:  TF
Novelty:  0.04558872
Score:  0.976
Data Source:  STRINGDB
HOXA7
Tbio
Family:  TF
Novelty:  0.00337527
Score:  0.976
Data Source:  STRINGDB
HOXC4
Tbio
Family:  TF
Novelty:  0.02206351
Score:  0.972
Data Source:  STRINGDB
HOXB4
Tbio
Family:  TF
Novelty:  0.00598207
Score:  0.972
Data Source:  STRINGDB
HOXB6
Tbio
Family:  TF
Novelty:  0.0176813
Score:  0.971
Data Source:  STRINGDB
HOXB7
Tbio
Family:  TF
Novelty:  0.00765378
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
12
96.2
BMI-adjusted waist-hip ratio
9
13
20
96
waist-hip ratio
5
15
16
91.3
diastolic blood pressure
5
7
10
91.1
waist circumference
1
7
7
86.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
12
96.2
BMI-adjusted waist-hip ratio
20
96
waist-hip ratio
16
91.3
diastolic blood pressure
10
91.1
waist circumference
7
86.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox protein Hox-A5
463310
Mouse
MGI:96177
15402
Rat
RGD:620609
79241
Dog
homeobox A5
VGNC:54769
482370
Cow
homeobox A5
VGNC:29913
768039
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox protein Hox-A5
Mouse
Rat
Dog
homeobox A5
Cow
homeobox A5
Publication Statistics
PubMed Score 199.45
PubMed score by year
PubTator Score 87.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title