Tbio HOOK3 Protein Hook homolog 3

Protein Summary

Description

Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q86VS8
• D3DSY8
• Q8NBH0
• Q9BY13
• h-hook3

Gene Name

• HOOK3

Ensembl ID

• ENST00000307602
• ENSP00000305699
• ENSG00000168172

Symbol

• HK3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
microRNA	0.78
histone modification site profile	0.73
cell line	0.71
transcription factor binding site profile	0.69

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Protein Hook Homolog 3

Protein / Enzyme Modulator / Kinase Modulator / Protein Hook Homolog 3

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Protein Hook Homolog 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.99   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.99   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0