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Tbio
HOOK3
Protein Hook homolog 3

Protein Summary
Description
Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307602
  • ENSP00000305699
  • ENSG00000168172

Symbol
  • HK3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
microRNA
0.78
histone modification site profile
0.73
cell line
0.71
transcription factor binding site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.9   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.9   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
AKTIP
Tbio
Novelty:  0.00315951
p_int:  1
Score:  0.996
Data Source:  BioPlex,STRINGDB
FAM160A2
Tbio
Novelty:  1.08224895
p_int:  0.999999996
p_ni:  1e-9
p_wrong:  3e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
HOOK1
Tbio
Novelty:  0.04136856
p_int:  0.999993576
p_ni:  0.000006424
Score:  0.982
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999990562
p_ni:  0.000009438
Data Source:  BioPlex
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999970811
p_ni:  0.000029189
Data Source:  BioPlex
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.999819684
p_ni:  0.000180316
Data Source:  BioPlex
FAM160A1
Tdark
Novelty:  2.71755347
p_int:  0.999548203
p_ni:  1.42e-7
p_wrong:  0.000451655
Score:  0.909
Data Source:  BioPlex,STRINGDB
MTMR4
Tbio
Family:  Enzyme
Novelty:  0.09166984
p_int:  0.999281638
p_ni:  0.000718346
p_wrong:  1.6e-8
Data Source:  BioPlex
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.999019116
p_ni:  0.000980884
Data Source:  BioPlex
ZC4H2
Tbio
Novelty:  0.04969464
p_int:  0.989755949
p_ni:  0.010244051
Score:  0.28
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
hook microtubule tethering protein 3
706093
Mouse
MGI:2443554
320191
Dog
hook microtubule tethering protein 3
VGNC:41742
475567
Horse
hook microtubule tethering protein 3
VGNC:18837
100053799
Cow
hook microtubule tethering protein 3
VGNC:50090
524648
Species
Name
OMA
EggNOG
Inparanoid
Macaque
hook microtubule tethering protein 3
Mouse
Dog
hook microtubule tethering protein 3
Horse
hook microtubule tethering protein 3
Cow
hook microtubule tethering protein 3
Publication Statistics
PubMed Score 19.90
PubMed score by year
PubTator Score 8.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title