You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HOOK2
Protein Hook homolog 2

Protein Summary
Description
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264827
  • ENSP00000264827
  • ENSG00000095066
  • ENST00000397668
  • ENSP00000380785

Symbol
  • HK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
PubMedID
0.65
transcription factor perturbation
0.61
tissue sample
0.6
transcription factor
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.91   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.91   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.999999905
p_ni:  9.2e-8
p_wrong:  3e-9
Score:  0.213
Data Source:  BioPlex,STRINGDB
AKTIP
Tbio
Novelty:  0.00315951
p_int:  0.9999999
p_ni:  1e-7
Score:  0.979
Data Source:  BioPlex,STRINGDB
FAM9B
Tdark
Novelty:  0.39508009
p_int:  0.999999398
p_ni:  6.02e-7
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.999693376
p_ni:  0.000306605
p_wrong:  2e-8
Data Source:  BioPlex
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.999580914
p_ni:  0.000419086
Data Source:  BioPlex
ALDH3A2
Tbio
Family:  Enzyme
Novelty:  0.0059198
p_int:  0.999148128
p_ni:  0.000851859
p_wrong:  1.3e-8
Data Source:  BioPlex
POC5
Tbio
Novelty:  0.09211907
p_int:  0.997341566
p_ni:  0.002658387
p_wrong:  4.7e-8
Score:  0.304
Data Source:  BioPlex,STRINGDB
FAM89B
Tbio
Novelty:  0.10306021
p_int:  0.995071034
p_ni:  0.004924793
p_wrong:  0.000004173
Data Source:  BioPlex
ST8SIA1
Tbio
Family:  Enzyme
Novelty:  0.02322808
p_int:  0.99290407
p_ni:  0.007095928
p_wrong:  2e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
SIGLECL1
Tdark
p_int:  0.988916367
p_ni:  0.011083633
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
7
7
98.4
reticulocyte measurement
3
5
6
97.9
mean corpuscular hemoglobin concentration
3
3
3
97
erythrocyte count
3
5
5
96.7
reticulocyte count
7
4
8
96.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
7
98.4
reticulocyte measurement
6
97.9
mean corpuscular hemoglobin concentration
3
97
erythrocyte count
5
96.7
reticulocyte count
8
96.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hook microtubule tethering protein 2
VGNC:10247
468738
Macaque
hook microtubule tethering protein 2
717752
Mouse
MGI:2181664
170833
Rat
RGD:1310171
304669
Dog
hook microtubule tethering protein 2
VGNC:41741
100856509
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hook microtubule tethering protein 2
Macaque
hook microtubule tethering protein 2
Mouse
Rat
Dog
hook microtubule tethering protein 2
Publication Statistics
PubMed Score 18.91
PubMed score by year
PubTator Score 7.45
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title