You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HOOK1
Protein Hook homolog 1

Protein Summary
Description
Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371208
  • ENSP00000360252
  • ENSG00000134709

Symbol
  • HK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.85
cell type or tissue
0.83
transcription factor
0.67
gene perturbation
0.66
microRNA
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.14   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.14   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
AKTIP
Tbio
Novelty:  0.00315951
p_int:  0.99999837
p_ni:  0.00000163
Score:  0.987
Data Source:  BioPlex,STRINGDB
HOOK3
Tbio
Novelty:  0.0553474
p_int:  0.999993576
p_ni:  0.000006424
Score:  0.982
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999992058
p_ni:  0.000007942
Data Source:  BioPlex
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.999448658
p_ni:  0.000551341
Score:  0.307
Data Source:  BioPlex,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.986479521
p_ni:  0.013520479
Data Source:  BioPlex
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.967353935
p_ni:  0.032646065
Data Source:  BioPlex
SELENBP1
Tbio
Novelty:  0.00758018
p_int:  0.964599485
p_ni:  0.035400513
p_wrong:  2e-9
Data Source:  BioPlex
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.960304294
p_ni:  0.039695706
Data Source:  BioPlex
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
p_int:  0.958788265
p_ni:  0.041211735
Data Source:  BioPlex
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.915349271
p_ni:  0.084650729
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hook microtubule tethering protein 1
VGNC:8050
456895
Macaque
hook microtubule tethering protein 1
693504
Mouse
MGI:1925213
77963
Rat
RGD:1309987
313370
Dog
hook microtubule tethering protein 1
VGNC:41740
479553
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hook microtubule tethering protein 1
Macaque
hook microtubule tethering protein 1
Mouse
Rat
Dog
hook microtubule tethering protein 1
Publication Statistics
PubMed Score 22.14
PubMed score by year
PubTator Score 13.08
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title