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Tbio
HOMER2
Homer protein homolog 2

Protein Summary
Description
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation through negative regulation of IL2 expression by inhibiting calcineurin-NFAT pathway activation through interaction with NFATC2 (PubMed:18218901). This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304231
  • ENSP00000305632
  • ENSG00000103942
  • ENST00000450735
  • ENSP00000407634

Symbol
  • CPD
  • ACPD
  • DFNA68
  • VESL-2
  • HOMER-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.81
transcription factor perturbation
0.74
virus perturbation
0.72
PubMedID
0.7
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.03   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.03   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
HOMER3
Tbio
Novelty:  0.04408998
p_int:  0.999999999
p_ni:  1e-9
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
HOMER1
Tbio
Novelty:  0.00264721
p_int:  0.999999998
p_ni:  1e-9
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
DBN1
Tbio
Novelty:  0.00556156
p_int:  0.999993298
p_ni:  0.000006702
Score:  0.87
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999964514
p_ni:  0.000035479
p_wrong:  7e-9
Data Source:  BioPlex
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.99993371
p_ni:  0.000062277
p_wrong:  0.000004013
Score:  0.754
Data Source:  BioPlex,STRINGDB
GRM1
Tchem
Family:  GPCR
Novelty:  0.00099764
Score:  0.979
Data Source:  Reactome,STRINGDB
SHANK1
Tbio
Novelty:  0.01475447
Score:  0.974
Data Source:  Reactome,STRINGDB
GRM5
Tchem
Family:  GPCR
Novelty:  0.00062552
Score:  0.973
Data Source:  Reactome,STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.963
Data Source:  Reactome,STRINGDB
SHANK2
Tbio
Novelty:  0.00710548
Score:  0.958
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 5 of 7
GRIN1
Tclin
Family:  Ion Channel
KEGG Distance:  4
Common Pathways:  1
GRIN2A
Tclin
Family:  Ion Channel
KEGG Distance:  4
Common Pathways:  1
GRIN3A
Tclin
Family:  Ion Channel
KEGG Distance:  4
Common Pathways:  1
GRIN2B
Tclin
Family:  Ion Channel
KEGG Distance:  4
Common Pathways:  1
GRIN2C
Tclin
Family:  Ion Channel
KEGG Distance:  4
Common Pathways:  1
Pathways (5)
Neurexins and neuroligins (R-HSA-6794361)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
5
5
83.1
hip circumference
1
3
3
63.6
glomerular filtration rate
1
1
1
50.6
high density lipoprotein cholesterol measurement
1
1
1
40.7
pro‐interleukin‐16 measurement
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
5
83.1
hip circumference
3
63.6
glomerular filtration rate
1
50.6
high density lipoprotein cholesterol measurement
1
40.7
pro‐interleukin‐16 measurement
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
homer scaffolding protein 2
693493
Mouse
MGI:1347354
26557
Rat
RGD:620705
29547
Dog
homer scaffolding protein 2 [Source:HGNC Symbol;Acc:HGNC:17513]
Horse
homer scaffold protein 2
VGNC:18833
100068333
Species
Name
OMA
EggNOG
Inparanoid
Macaque
homer scaffolding protein 2
Mouse
Rat
Dog
homer scaffolding protein 2 [Source:HGNC Symbol;Acc:HGNC:17513]
Horse
homer scaffold protein 2
Publication Statistics
PubMed Score 129.03
PubMed score by year
PubTator Score 76.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title