Tbio HOMER1 Homer protein homolog 1

Protein Summary

Description

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86YM7
• B2R688
• O96003
• Q86YM5
• Homer-1

Gene Name

• HOMER1

Ensembl ID

• ENST00000282260
• ENSP00000282260
• ENSG00000152413
• ENST00000334082
• ENSP00000334382
• ENST00000508576
• ENSP00000426651

Symbol

• SYN47
• HOMER
• SYN47
• Ves-1
• HOMER1A
• HOMER1B
• HOMER1C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
transcription factor binding site profile	0.83
virus perturbation	0.83
histone modification site profile	0.75
biological process	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 505.15   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 316   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 505.15   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0