Tbio HOGA1 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Protein Summary

Description

Catalyzes the final step in the metabolic pathway of hydroxyproline. The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q86XE5
• A8K075
• Q5T680
• Q5T684
• Q711P0
• Q8N9F2
• Q96EV5

Gene Name

• HOGA1

Ensembl ID

• ENST00000370646
• ENSP00000359680
• ENSG00000241935
• ENST00000370647
• ENSP00000359681

Symbol

• C10orf65
• DHDPSL
• HP3
• NPL2
• DHDPS2
• DHDPSL
• C10orf65

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.83
tissue sample	0.65
cellular component	0.56
metabolite	0.45
biological process	0.44

Protein Classes

PANTHER Classes

Protein / Lyase / 4-hydroxy-2-oxoglutarate Aldolase, Mitochondrial

DTO Classes

Protein / Enzyme / Lyase / 4-hydroxy-2-oxoglutarate Aldolase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.31   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 19   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.31   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0