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Tbio
HNRNPM
Heterogeneous nuclear ribonucleoprotein M

Protein Summary
Description
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325495
  • ENSP00000325376
  • ENSG00000099783
  • ENST00000348943
  • ENSP00000325732

Symbol
  • HNRPM
  • NAGR1
  • CEAR
  • HNRPM
  • HTGR1
  • NAGR1
  • HNRPM4
  • HNRNPM4
  • hnRNP M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
hub protein
1
interacting protein
1
disease perturbation
0.93
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.66   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 422   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.66   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 422   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (342)
HNRNPH1
Tbio
Novelty:  0.01273351
Score:  0.999
Data Source:  STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
Score:  0.999
Data Source:  STRINGDB
HNRNPK
Tbio
Novelty:  0.00354731
Score:  0.999
Data Source:  STRINGDB
SRSF2
Tbio
Novelty:  0.00207072
Score:  0.999
Data Source:  STRINGDB
PLRG1
Tbio
Novelty:  0.05163655
Score:  0.999
Data Source:  STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
Score:  0.999
Data Source:  STRINGDB
HNRNPC
Tbio
Novelty:  0.00136097
Score:  0.998
Data Source:  STRINGDB
HNRNPF
Tbio
Novelty:  0.01833966
Score:  0.998
Data Source:  STRINGDB
SRSF3
Tbio
Novelty:  0.01015895
Score:  0.998
Data Source:  STRINGDB
HNRNPA2B1
Tbio
Novelty:  0.00404935
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
FGFR2 alternative splicing (R-HSA-6803529)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR2 alternative splicing
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Name
Explore in Pharos
Explore in Source
FGFR2 alternative splicing
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Signal Transduction
Signaling by FGFR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
13
10
22
4
99.7
triglyceride measurement
9
4
13
98.7
apolipoprotein A 1 measurement
2
4
5
98
reticulocyte measurement
3
4
6
83.7
mean corpuscular hemoglobin concentration
1
1
1
83.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
22
4
99.7
triglyceride measurement
13
98.7
apolipoprotein A 1 measurement
5
98
reticulocyte measurement
6
83.7
mean corpuscular hemoglobin concentration
1
83.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein M
VGNC:2356
455671
Macaque
heterogeneous nuclear ribonucleoprotein M
711941
Mouse
MGI:1926465
76936
Rat
RGD:620369
116655
Dog
heterogeneous nuclear ribonucleoprotein M
VGNC:41734
476725
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein M
Macaque
heterogeneous nuclear ribonucleoprotein M
Mouse
Rat
Dog
heterogeneous nuclear ribonucleoprotein M
Publication Statistics
PubMed Score 85.66
PubMed score by year
PubTator Score 730.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title