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Tbio
HNRNPLL
Heterogeneous nuclear ribonucleoprotein L-like

Protein Summary
Description
RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409328
  • ENSP00000386575
  • ENSG00000143889
  • ENST00000409636
  • ENSP00000387088
  • ENST00000410076
  • ENSP00000386695
  • ENST00000449105
  • ENSP00000390625

Symbol
  • HNRPLL
  • SRRF
  • SRRF
  • HNRPLL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
transcription factor
0.81
interacting protein
0.8
gene perturbation
0.74
protein complex
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.56   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.56   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
SETD2
Tchem
Family:  Epigenetic
Novelty:  0.00178899
p_int:  0.999990997
p_ni:  0.000009003
Score:  0.212
Data Source:  BioPlex,STRINGDB
ZFHX4
Tbio
Family:  TF
Novelty:  0.06538087
p_int:  0.999948077
p_ni:  0.000051886
p_wrong:  3.7e-8
Data Source:  BioPlex
ESRP2
Tbio
Novelty:  0.05084007
p_int:  0.999929453
p_ni:  1.76e-7
p_wrong:  0.000070371
Score:  0.522
Data Source:  BioPlex,STRINGDB
PLCD4
Tbio
Family:  Enzyme
Novelty:  0.07014141
p_int:  0.999886686
p_ni:  0.000113314
Data Source:  BioPlex
LIMK2
Tchem
Family:  Kinase
Novelty:  0.0153308
p_int:  0.999876127
p_ni:  0.000123873
Data Source:  BioPlex
MINDY3
Tbio
Novelty:  0.02865765
p_int:  0.999769237
p_ni:  0.000230647
p_wrong:  1.15e-7
Score:  0.19
Data Source:  BioPlex,STRINGDB
PPHLN1
Tbio
Novelty:  0.21311177
p_int:  0.999662255
p_ni:  0.000337744
Data Source:  BioPlex
SAMD11
Tdark
Novelty:  0.32977476
p_int:  0.999355358
p_ni:  0.000642583
p_wrong:  0.000002059
Data Source:  BioPlex
PHYHD1
Tdark
Family:  Enzyme
Novelty:  0.43207644
p_int:  0.999342395
p_ni:  0.000657605
Score:  0.195
Data Source:  BioPlex,STRINGDB
MBNL2
Tbio
Novelty:  0.02398556
p_int:  0.99903202
p_ni:  0.000817122
p_wrong:  0.000150858
Score:  0.24
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
10.3
body mass index
1
1
1
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
10.3
body mass index
1
3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein L like
VGNC:6390
470353
Macaque
heterogeneous nuclear ribonucleoprotein L like
710841
Mouse
MGI:1919942
72692
Rat
RGD:1305861
313842
Dog
heterogeneous nuclear ribonucleoprotein L like
VGNC:41733
100856681
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein L like
Macaque
heterogeneous nuclear ribonucleoprotein L like
Mouse
Rat
Dog
heterogeneous nuclear ribonucleoprotein L like
Publication Statistics
PubMed Score 33.56
PubMed score by year
PubTator Score 11.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title