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Tbio
HNRNPK
Heterogeneous nuclear ribonucleoprotein K

Protein Summary
Description
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351839
  • ENSP00000317788
  • ENSG00000165119
  • ENST00000360384
  • ENSP00000353552
  • ENST00000376263
  • ENSP00000365439
  • ENST00000376281
  • ENSP00000365458

Symbol
  • HNRPK
  • AUKS
  • CSBP
  • TUNP
  • HNRPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
co-expressed gene
0.98
transcription factor binding site profile
0.95
kinase
0.92


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.31   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 552   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.31   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 552   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (469)
SNX33
Tbio
Novelty:  0.11762505
p_int:  0.999998655
p_ni:  0.000001345
Score:  0.188
Data Source:  BioPlex,STRINGDB
FNBP1L
Tbio
Novelty:  0.01235857
p_int:  0.99999862
p_ni:  0.000001378
p_wrong:  3e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
CASP2
Tchem
Family:  Enzyme
Novelty:  0.00189892
p_int:  0.999993852
p_ni:  3.01e-7
p_wrong:  0.000005848
Score:  0.38
Data Source:  BioPlex,STRINGDB
KLHL23
Tdark
Novelty:  0.64141058
p_int:  0.999382267
p_ni:  0.000617733
Score:  0.173
Data Source:  BioPlex,STRINGDB
TRMT1L
Tdark
Novelty:  0.30029348
p_int:  0.990581252
p_ni:  0.009418748
Score:  0.193
Data Source:  BioPlex,STRINGDB
SNX9
Tbio
Novelty:  0.01737783
p_int:  0.980064968
p_ni:  0.019935032
Score:  0.175
Data Source:  BioPlex,STRINGDB
PRMT8
Tchem
Family:  Epigenetic
Novelty:  0.04213384
p_int:  0.974303968
p_ni:  0.025696032
Score:  0.172
Data Source:  BioPlex,STRINGDB
TRMT61B
Tbio
Family:  Enzyme
Novelty:  0.32929047
p_int:  0.964886119
p_ni:  0.035113881
Score:  0.156
Data Source:  BioPlex,STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
p_int:  0.957704258
p_ni:  0.042214197
p_wrong:  0.000081545
Score:  0.196
Data Source:  BioPlex,STRINGDB
YARS2
Tbio
Family:  Enzyme
Novelty:  0.00522139
p_int:  0.82239954
p_ni:  0.17760046
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
SUMO E3 ligases SUMOylate target proteins
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of proteins
Post-translational protein modification
Processing of Capped Intron-Containing Pre-mRNA
SUMO E3 ligases SUMOylate target proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
89.9
sex hormone-binding globulin measurement
6
2
6
89.2
triglyceride measurement
3
3
3
86.9
myeloid white cell count
1
1
1
80.6
eosinophil percentage of leukocytes
1
1
1
80.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
89.9
sex hormone-binding globulin measurement
6
89.2
triglyceride measurement
3
86.9
myeloid white cell count
1
80.6
eosinophil percentage of leukocytes
1
80.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
heterogeneous nuclear ribonucleoprotein K
709112
Mouse
MGI:99894
15387
Rat
RGD:71058
117282
Dog
heterogeneous nuclear ribonucleoprotein K
100855638
Horse
heterogeneous nuclear ribonucleoprotein K
VGNC:18828
100052735
Species
Name
OMA
EggNOG
Inparanoid
Macaque
heterogeneous nuclear ribonucleoprotein K
Mouse
Rat
Dog
heterogeneous nuclear ribonucleoprotein K
Horse
heterogeneous nuclear ribonucleoprotein K
Publication Statistics
PubMed Score 318.31
PubMed score by year
PubTator Score 227.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title