Tbio HNRNPH1 Heterogeneous nuclear ribonucleoprotein H

Protein Summary

Description

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• P31943
• B3KW86
• D3DWQ2
• Q6IBM4
• hnRNP H

Gene Name

• HNRNPH1

Ensembl ID

• ENST00000356731
• ENSP00000349168
• ENSG00000169045
• ENST00000393432
• ENSP00000377082
• ENST00000442819
• ENSP00000397797
• ENST00000639490
• ENSP00000492211
• ENSG00000284254
• ENST00000643274
• ENSP00000496484

Symbol

• HNRPH
• HNRPH1
• HNRPH
• HNRPH1
• hnRNPH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
hub protein	0.99
transcription factor binding site profile	0.98
transcription factor perturbation	0.91
protein complex	0.83

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Heterogeneous Nuclear Ribonucleoprotein H

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Heterogeneous Nuclear Ribonucleoprotein H

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.28   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.28   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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GENEVA

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (361)

Explore Interacting Targets

1 – 10 of 361

• See Interactions on String-DB

PLOD1

Tbio

Family:  Enzyme

Novelty:  0.00905345

p_int:  0.999914433

p_ni:  0.000085567

Score:  0.188

Data Source:  BioPlex,STRINGDB

NAGK

Tbio

Family:  Kinase

Novelty:  0.01603908

p_int:  0.998952295

p_ni:  0.001047705

Score:  0.186

Data Source:  BioPlex,STRINGDB

ARHGEF39

Tdark

Novelty:  0.30447134

p_int:  0.997135557

p_ni:  0.002864444

Data Source:  BioPlex

PLOD3

Tbio

Family:  Enzyme

Novelty:  0.02211629

p_int:  0.995580066

p_ni:  0.004419934

Data Source:  BioPlex

COPRS

Tbio

Novelty:  0.03545787

p_int:  0.976850004

p_ni:  0.023149997

Data Source:  BioPlex

HNRNPL

Tbio

Novelty:  0.01048413

Score:  0.999

Data Source:  STRINGDB

HNRNPK

Tbio

Novelty:  0.00354731

Score:  0.999

Data Source:  STRINGDB

HNRNPA2B1

Tbio

Novelty:  0.00404935

Score:  0.999

Data Source:  STRINGDB

HNRNPM

Tbio

Novelty:  0.0125566

Score:  0.999

Data Source:  STRINGDB

HNRNPA0

Tbio

Novelty:  0.10233768

Score:  0.999

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (38)

Reactome (9)

WikiPathways (29)

FGFR2 alternative splicing (R-HSA-6803529)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	FGFR2 alternative splicing	26 targets	R-HSA-6803529
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by FGFR	87 targets	R-HSA-190236

Name	Explore in Pharos	Explore in Source
FGFR2 alternative splicing	26 targets	R-HSA-6803529
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Signal Transduction	2704 targets	R-HSA-162582
Signaling by FGFR	87 targets	R-HSA-190236

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (2)

Components (5)

Processes (5)

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1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from Direct Assay (IDA)	UniProtKB
poly(U) RNA binding	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (14)

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5

1 – 5 of 14

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
myeloid white cell count	EFO_0007988	ENSG00000169045	2	2	2		81.8
myeloid white cell count	EFO_0007988	ENSG00000284254	2	2	2		81.8
leukocyte count	EFO_0004308	ENSG00000169045	2	2	2		74
leukocyte count	EFO_0004308	ENSG00000284254	2	2	2		74
neutrophil count	EFO_0004833	ENSG00000169045	1	1	1		69.8

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
myeloid white cell count	EFO_0007988	2		81.8
myeloid white cell count	EFO_0007988	2		81.8
leukocyte count	EFO_0004308	2		74
leukocyte count	EFO_0004308	2		74
neutrophil count	EFO_0004833	1		69.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Isopeptide bond
Methylation
mRNA processing
mRNA splicing
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
leukocyte count
lymphocyte count
lymphocyte percentage of leukocytes
monocyte percentage of leukocytes
myeloid white cell count
neutrophil count
neutrophil percentage of leukocytes

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	heterogeneous nuclear ribonucleoprotein H1	MGI:1891925	59013
Rat	heterogeneous nuclear ribonucleoprotein H1	RGD:620840	140931
Horse	heterogeneous nuclear ribonucleoprotein H1	VGNC:18825	100067495
Cow	heterogeneous nuclear ribonucleoprotein H1	VGNC:52245	541202
Pig	heterogeneous nuclear ribonucleoprotein H1		100519535

Species	Name	OMA	EggNOG	Inparanoid
Mouse	heterogeneous nuclear ribonucleoprotein H1
Rat	heterogeneous nuclear ribonucleoprotein H1
Horse	heterogeneous nuclear ribonucleoprotein H1
Cow	heterogeneous nuclear ribonucleoprotein H1
Pig	heterogeneous nuclear ribonucleoprotein H1

Publication Statistics

PubMed Score 86.28

PubMed score by year

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PubTator Score 31.10

PubTator score by year

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Related Publications

Text Mined References (64)

GeneRif Annotations (27)

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PMID	Year	Title