Tbio HNRNPD Heterogeneous nuclear ribonucleoprotein D0

Protein Summary

Description

Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14103
• A8K9J2
• P07029
• Q01858
• Q14100
• Q14101
• Q14102
• Q4W5A1
• Q9UCE8
• Q9UCE9
• hnRNP D0

Gene Name

• HNRNPD

Ensembl ID

• ENST00000313899
• ENSP00000313199
• ENSG00000138668
• ENST00000352301
• ENSP00000305860
• ENST00000353341
• ENSP00000313327

Symbol

• AUF1
• HNRPD
• P37
• AUF1
• AUF1A
• HNRPD
• hnRNPD0

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
interacting protein	1
transcription factor perturbation	0.98
hub protein	0.97
virus perturbation	0.96

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.26   (req: < 5)

Gene RIFs: 86   (req: <= 3)

Antibodies: 407   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.26   (req: >= 5)

Gene RIFs: 86   (req: > 3)

Antibodies: 407   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (353)

Explore Interacting Targets

1 – 10 of 353

• See Interactions on String-DB

EXOSC2

Tbio

Novelty:  0.08163283

Score:  0.995

Data Source:  STRINGDB

PTBP1

Tbio

Novelty:  0.00184728

Score:  0.993

Data Source:  STRINGDB

HNRNPL

Tbio

Novelty:  0.01048413

Score:  0.992

Data Source:  STRINGDB

FUS

Tbio

Novelty:  0.00065625

Score:  0.991

Data Source:  STRINGDB

HNRNPC

Tbio

Novelty:  0.00136097

Score:  0.991

Data Source:  STRINGDB

HNRNPA2B1

Tbio

Novelty:  0.00404935

Score:  0.988

Data Source:  STRINGDB

HNRNPK

Tbio

Novelty:  0.00354731

Score:  0.985

Data Source:  STRINGDB

TNPO1

Tbio

Novelty:  0.01278619

Score:  0.985

Data Source:  STRINGDB

HNRNPA1

Tchem

Novelty:  0.0020871

Score:  0.985

Data Source:  STRINGDB

HNRNPF

Tbio

Novelty:  0.01833966

Score:  0.984

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (6)

WikiPathways (2)

AUF1 (hnRNP D0) binds and destabilizes mRNA (R-HSA-450408)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AUF1 (hnRNP D0) binds and destabilizes mRNA	56 targets	R-HSA-450408
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	Regulation of mRNA stability by proteins that bind AU-rich elements	90 targets	R-HSA-450531
Reactome	mRNA Splicing	188 targets	R-HSA-72172

Name	Explore in Pharos	Explore in Source
AUF1 (hnRNP D0) binds and destabilizes mRNA	56 targets	R-HSA-450408
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Regulation of mRNA stability by proteins that bind AU-rich elements	90 targets	R-HSA-450531
mRNA Splicing	188 targets	R-HSA-72172

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (43)

Functions (10)

Components (5)

Processes (28)

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GO Term	Evidence	Assigned by
RNA binding	Inferred from Direct Assay (IDA)	UniProtKB
telomeric DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
AT DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
mRNA 3'-UTR AU-rich region binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
mRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
sequence-specific double-stranded DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
chromatin binding	Inferred from Electronic Annotation (IEA)	Ensembl
histone deacetylase binding	Inferred from Electronic Annotation (IEA)	Ensembl
transcription factor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (6)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	3	2	3		75
chronotype measurement	EFO_0008328	2	2	1	1	72.8
self reported educational attainment	EFO_0004784	1	1	1		59
alkaline phosphatase measurement	EFO_0004533	1	1	1		48.5
BMI-adjusted waist circumference	EFO_0007789	1	1	1		46.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	3		75
chronotype measurement	EFO_0008328	1	1	72.8
self reported educational attainment	EFO_0004784	1		59
alkaline phosphatase measurement	EFO_0004533	1		48.5
BMI-adjusted waist circumference	EFO_0007789	1		46.9

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UniProt Keyword Find Similar Targets

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3D-structure
Acetylation
Alternative splicing
Biological rhythms
Complete proteome
Cytoplasm
Direct protein sequencing
DNA-binding
Isopeptide bond
Methylation

GWAS Trait Find Similar Targets

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alkaline phosphatase measurement
BMI-adjusted waist circumference
chronotype measurement
mathematical ability
self reported educational attainment
sex hormone-binding globulin measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	heterogeneous nuclear ribonucleoprotein D	VGNC:751	461216
Mouse	heterogeneous nuclear ribonucleoprotein D	MGI:101947	11991
Rat	heterogeneous nuclear ribonucleoprotein D	RGD:620365	79256
Dog	heterogeneous nuclear ribonucleoprotein D		478450
Horse	heterogeneous nuclear ribonucleoprotein D	VGNC:51197	100060733

Species	Name	OMA	EggNOG	Inparanoid
Chimp	heterogeneous nuclear ribonucleoprotein D
Mouse	heterogeneous nuclear ribonucleoprotein D
Rat	heterogeneous nuclear ribonucleoprotein D
Dog	heterogeneous nuclear ribonucleoprotein D
Horse	heterogeneous nuclear ribonucleoprotein D

Publication Statistics

PubMed Score 202.26

PubMed score by year

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PubTator Score 153.55

PubTator score by year

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Related Publications

Text Mined References (131)

GeneRif Annotations (86)

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PMID	Year	Title