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Tbio
HNRNPD
Heterogeneous nuclear ribonucleoprotein D0

Protein Summary
Description
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313899
  • ENSP00000313199
  • ENSG00000138668
  • ENST00000352301
  • ENSP00000305860
  • ENST00000353341
  • ENSP00000313327

Symbol
  • AUF1
  • HNRPD
  • P37
  • AUF1
  • AUF1A
  • HNRPD
  • hnRNPD0
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
transcription factor perturbation
0.98
hub protein
0.97
virus perturbation
0.96


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.26   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 407   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.26   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 407   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (353)
EXOSC2
Tbio
Novelty:  0.08163283
Score:  0.995
Data Source:  STRINGDB
PTBP1
Tbio
Novelty:  0.00184728
Score:  0.993
Data Source:  STRINGDB
HNRNPL
Tbio
Novelty:  0.01048413
Score:  0.992
Data Source:  STRINGDB
FUS
Tbio
Novelty:  0.00065625
Score:  0.991
Data Source:  STRINGDB
HNRNPC
Tbio
Novelty:  0.00136097
Score:  0.991
Data Source:  STRINGDB
HNRNPA2B1
Tbio
Novelty:  0.00404935
Score:  0.988
Data Source:  STRINGDB
HNRNPK
Tbio
Novelty:  0.00354731
Score:  0.985
Data Source:  STRINGDB
TNPO1
Tbio
Novelty:  0.01278619
Score:  0.985
Data Source:  STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
Score:  0.985
Data Source:  STRINGDB
HNRNPF
Tbio
Novelty:  0.01833966
Score:  0.984
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
AUF1 (hnRNP D0) binds and destabilizes mRNA (R-HSA-450408)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AUF1 (hnRNP D0) binds and destabilizes mRNA
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome
mRNA Splicing
Name
Explore in Pharos
Explore in Source
AUF1 (hnRNP D0) binds and destabilizes mRNA
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Regulation of mRNA stability by proteins that bind AU-rich elements
mRNA Splicing
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
75
chronotype measurement
2
2
1
1
72.8
self reported educational attainment
1
1
1
59
alkaline phosphatase measurement
1
1
1
48.5
BMI-adjusted waist circumference
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
75
chronotype measurement
1
1
72.8
self reported educational attainment
1
59
alkaline phosphatase measurement
1
48.5
BMI-adjusted waist circumference
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein D
VGNC:751
461216
Mouse
MGI:101947
11991
Rat
RGD:620365
79256
Dog
heterogeneous nuclear ribonucleoprotein D
478450
Horse
heterogeneous nuclear ribonucleoprotein D
VGNC:51197
100060733
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein D
Mouse
Rat
Dog
heterogeneous nuclear ribonucleoprotein D
Horse
heterogeneous nuclear ribonucleoprotein D
Publication Statistics
PubMed Score 202.26
PubMed score by year
PubTator Score 153.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title