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Tbio
HNRNPC
Heterogeneous nuclear ribonucleoproteins C1/C2

Protein Summary
Description
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000420743
  • ENSP00000404848
  • ENSG00000092199
  • ENST00000430246
  • ENSP00000442816
  • ENST00000553300
  • ENSP00000450544
  • ENST00000554455
  • ENSP00000451291
  • ENST00000554969
  • ENSP00000450725
  • ENST00000555883
  • ENSP00000450629
  • ENST00000556628
  • ENSP00000451652
  • ENST00000556897
  • ENSP00000451176
  • ENST00000557201
  • ENSP00000452276

Symbol
  • HNRPC
  • C1
  • C2
  • HNRNP
  • HNRPC
  • SNRPC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
drug perturbation
1
hub protein
1
interacting protein
1
ligand (protein) perturbation
0.99


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 829.09   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 430   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 829.09   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 430   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (571)
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.988945952
p_ni:  0.011054048
Score:  0.96
Data Source:  BioPlex,STRINGDB
ILF2
Tbio
Novelty:  0.01598188
p_int:  0.946699083
p_ni:  0.053300917
Score:  0.974
Data Source:  BioPlex,STRINGDB
GSPT2
Tchem
Family:  Enzyme
Novelty:  0.08140512
p_int:  0.908309639
p_ni:  0.091690361
Score:  0.435
Data Source:  BioPlex,STRINGDB
MTMR7
Tbio
Family:  Enzyme
Novelty:  0.1707096
p_int:  0.857309764
p_ni:  0.142690236
Score:  0.23
Data Source:  BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.83796576
p_ni:  0.16203424
Data Source:  BioPlex
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.837910032
p_ni:  0.162089968
Data Source:  BioPlex
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.827882717
p_ni:  0.172117283
Data Source:  BioPlex
RBM47
Tbio
Novelty:  0.04787234
p_int:  0.793681836
p_ni:  0.206318164
Score:  0.288
Data Source:  BioPlex,STRINGDB
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.762066957
p_ni:  0.237933043
Data Source:  BioPlex
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.750932798
p_ni:  0.249067202
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
SUMO E3 ligases SUMOylate target proteins
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of proteins
Post-translational protein modification
Processing of Capped Intron-Containing Pre-mRNA
SUMO E3 ligases SUMOylate target proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
2
2
49.9
mathematical ability
1
1
1
25.8
electrocardiography
1
1
1
20
body height
1
1
1
16.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
49.9
mathematical ability
1
25.8
electrocardiography
1
20
body height
1
16.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
heterogeneous nuclear ribonucleoprotein C (C1/C2)
706423
Mouse
MGI:107795
15381
Dog
heterogeneous nuclear ribonucleoprotein C (C1/C2)
475399
Platypus
heterogeneous nuclear ribonucleoprotein C
100088194
Species
Name
OMA
EggNOG
Inparanoid
Macaque
heterogeneous nuclear ribonucleoprotein C (C1/C2)
Mouse
Dog
heterogeneous nuclear ribonucleoprotein C (C1/C2)
Platypus
heterogeneous nuclear ribonucleoprotein C
Publication Statistics
PubMed Score 829.09
PubMed score by year
PubTator Score 2424.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title