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Tbio
HNRNPA2B1
Heterogeneous nuclear ribonucleoproteins A2/B1

Protein Summary
Description
Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA se ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354667
  • ENSP00000346694
  • ENSG00000122566
  • ENST00000356674
  • ENSP00000349101
  • ENST00000360787
  • ENSP00000354021
  • ENST00000608362
  • ENSP00000497298

Symbol
  • HNRPA2B1
  • RNPA2
  • HNRPA2
  • HNRPB1
  • SNRPB1
  • HNRNPA2
  • HNRNPB1
  • IBMPFD2
  • HNRPA2B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
kinase perturbation
0.99
transcription factor perturbation
0.99
transcription factor binding site profile
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.63   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 424   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.63   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 424   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0