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Tchem
HNRNPA1
Heterogeneous nuclear ribonucleoprotein A1

Protein Summary
Description
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233). (Microbial infection) May play a role in HCV RNA replication. This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340913
  • ENSP00000341826
  • ENSG00000135486
  • ENST00000546500
  • ENSP00000448617
  • ENST00000547276
  • ENSP00000447260
  • ENST00000547566
  • ENSP00000449913

Symbol
  • HNRPA1
  • UP 1
  • ALS19
  • ALS20
  • HNRPA1
  • IBMPFD3
  • HNRPA1L3
  • hnRNP A1
  • hnRNP-A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
transcription factor perturbation
0.97
co-expressed gene
0.91
transcription factor binding site profile
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.9   (req: < 5)
Gene RIFs: 125   (req: <= 3)
Antibodies: 452   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.9   (req: >= 5)
Gene RIFs: 125   (req: > 3)
Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (588)
HNRNPA1L2
Tdark
Novelty:  0.46233313
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.796
Data Source:  BioPlex,STRINGDB
NGRN
Tbio
Novelty:  0.11162143
p_int:  0.999108043
p_ni:  0.000891956
p_wrong:  1e-9
Data Source:  BioPlex
YARS2
Tbio
Family:  Enzyme
Novelty:  0.00522139
p_int:  0.99865722
p_ni:  0.00134278
Score:  0.26
Data Source:  BioPlex,STRINGDB
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
p_int:  0.996787147
p_ni:  0.003212853
Data Source:  BioPlex
MTERF3
Tdark
Novelty:  0.06316581
p_int:  0.995784995
p_ni:  0.004215005
Score:  0.347
Data Source:  BioPlex,STRINGDB
MRPL52
Tdark
Novelty:  0.72949349
p_int:  0.993048362
p_ni:  0.00691672
p_wrong:  0.000034919
Score:  0.259
Data Source:  BioPlex,STRINGDB
TRUB2
Tdark
Family:  Enzyme
Novelty:  0.4130414
p_int:  0.992634827
p_ni:  0.007365173
Score:  0.355
Data Source:  BioPlex,STRINGDB
FASTKD2
Tbio
Family:  Enzyme
Novelty:  0.12614412
p_int:  0.992389397
p_ni:  0.007610603
Score:  0.653
Data Source:  BioPlex,STRINGDB
PTCD1
Tdark
Novelty:  0.17182155
p_int:  0.989228893
p_ni:  0.010771107
Score:  0.347
Data Source:  BioPlex,STRINGDB
FAM120A
Tbio
Novelty:  0.1054654
p_int:  0.988852077
p_ni:  0.011147923
Score:  0.525
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
FGFR2 alternative splicing (R-HSA-6803529)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR2 alternative splicing
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Name
Explore in Pharos
Explore in Source
FGFR2 alternative splicing
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Signal Transduction
Signaling by FGFR
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred by Curator (IC)
HGNC
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
6
9
99.5
platelet count
5
5
6
8.7
98.4
red blood cell distribution width
4
2
6
95.6
mean corpuscular volume
1
2
2
94.4
reticulocyte measurement
2
2
2
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
99.5
platelet count
6
8.7
98.4
red blood cell distribution width
6
95.6
mean corpuscular volume
2
94.4
reticulocyte measurement
2
88
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:69234
29578
Horse
heterogeneous nuclear ribonucleoprotein A1
100034153
Pig
heterogeneous nuclear ribonucleoprotein A1
768103
Xenopus
heterogeneous nuclear ribonucleoprotein A1
XB-GENE-493963
496507
C. elegans
177101
Species
Name
OMA
EggNOG
Inparanoid
Rat
Horse
heterogeneous nuclear ribonucleoprotein A1
Pig
heterogeneous nuclear ribonucleoprotein A1
Xenopus
heterogeneous nuclear ribonucleoprotein A1
C. elegans
Publication Statistics
PubMed Score 506.90
PubMed score by year
PubTator Score 411.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title