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Tbio
HNRNPA0
Heterogeneous nuclear ribonucleoprotein A0

Protein Summary
Description
mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314940
  • ENSP00000316042
  • ENSG00000177733

Symbol
  • HNRPA0
  • HNRPA0
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.96
protein complex
0.8
hub protein
0.71
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.91   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.91   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (267)
HNRNPH1
Tbio
Novelty:  0.01273351
Score:  0.999
Data Source:  STRINGDB
HNRNPL
Tbio
Novelty:  0.01048413
Score:  0.999
Data Source:  STRINGDB
PTBP1
Tbio
Novelty:  0.00184728
Score:  0.998
Data Source:  STRINGDB
SRSF1
Tbio
Novelty:  0.00074446
Score:  0.998
Data Source:  STRINGDB
HNRNPK
Tbio
Novelty:  0.00354731
Score:  0.997
Data Source:  STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
Score:  0.997
Data Source:  STRINGDB
HNRNPM
Tbio
Novelty:  0.0125566
Score:  0.996
Data Source:  STRINGDB
HNRNPF
Tbio
Novelty:  0.01833966
Score:  0.996
Data Source:  STRINGDB
HNRNPC
Tbio
Novelty:  0.00136097
Score:  0.996
Data Source:  STRINGDB
RBMX
Tbio
Novelty:  0.01705784
Score:  0.994
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
1
2
56.2
hematocrit
2
2
2
48.5
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
56.2
hematocrit
2
48.5
0
1.1
21.5
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
-
Mouse
MGI:1924384
77134
Dog
heterogeneous nuclear ribonucleoprotein A0
VGNC:51722
481524
Cow
heterogeneous nuclear ribonucleoprotein A0
VGNC:52238
540311
Platypus
heterogeneous nuclear ribonucleoprotein A0
100090450
Species
Name
OMA
EggNOG
Inparanoid
Macaque
-
Mouse
Dog
heterogeneous nuclear ribonucleoprotein A0
Cow
heterogeneous nuclear ribonucleoprotein A0
Platypus
heterogeneous nuclear ribonucleoprotein A0
Publication Statistics
PubMed Score 8.91
PubMed score by year
PubTator Score 5.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title