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Tchem
HNF4A
Hepatocyte nuclear factor 4-alpha

Protein Summary
Description
Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine. The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316099
  • ENSP00000312987
  • ENSG00000101076
  • ENST00000316673
  • ENSP00000315180
  • ENST00000415691
  • ENSP00000412111
  • ENST00000443598
  • ENSP00000410911
  • ENST00000457232
  • ENSP00000396216
  • ENST00000609795
  • ENSP00000476609

Symbol
  • HNF4
  • NR2A1
  • TCF14
  • TCF
  • HNF4
  • MODY
  • FRTS4
  • MODY1
  • NR2A1
  • TCF14
  • HNF4a7
  • HNF4a8
  • HNF4a9
  • NR2A21
  • HNF4alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
microRNA
0.96
biological process
0.92
hub protein
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2556.14   (req: < 5)
Gene RIFs: 346   (req: <= 3)
Antibodies: 869   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2556.14   (req: >= 5)
Gene RIFs: 346   (req: > 3)
Antibodies: 869   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0