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Tbio
HNF1B
Hepatocyte nuclear factor 1-beta

Protein Summary
Description
Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610754
  • ENSP00000484591
  • ENSG00000276194
  • ENST00000617811
  • ENSP00000480291
  • ENSG00000275410
  • ENST00000621123
  • ENSP00000482711
  • ENST00000633792
  • ENSP00000488080

Symbol
  • TCF2
  • FJHN
  • HNF2
  • LFB3
  • TCF2
  • HPC11
  • LF-B3
  • MODY5
  • TCF-2
  • VHNF1
  • HNF-1B
  • HNF1beta
  • HNF-1-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
trait
0.99
biological term
0.88
protein domain
0.85
phenotype
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 562.06   (req: < 5)
Gene RIFs: 187   (req: <= 3)
Antibodies: 481   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 562.06   (req: >= 5)
Gene RIFs: 187   (req: > 3)
Antibodies: 481   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0