You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
HMOX2
Heme oxygenase 2

Protein Summary
Description
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219700
  • ENSP00000219700
  • ENSG00000103415
  • ENST00000398595
  • ENSP00000381595
  • ENST00000406590
  • ENSP00000385100
  • ENST00000414777
  • ENSP00000391637
  • ENST00000458134
  • ENSP00000394103
  • ENST00000570646
  • ENSP00000459214
  • ENST00000575120
  • ENSP00000460926
  • ENST00000612525
  • ENSP00000481295
  • ENSG00000277424
  • ENST00000615778
  • ENSP00000484422
  • ENST00000619528
  • ENSP00000484423
  • ENST00000619913
  • ENSP00000484467
  • ENST00000620445
  • ENSP00000478785
  • ENST00000621065
  • ENSP00000481811
  • ENST00000622146
  • ENSP00000483319
  • ENST00000631540
  • ENSP00000487673
  • ENST00000631677
  • ENSP00000488579
  • ENST00000632458
  • ENSP00000488880
  • ENST00000633319
  • ENSP00000488769

Symbol
  • HO2
  • HO-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
virus perturbation
0.88
kinase perturbation
0.84
transcription factor
0.71
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 513.3   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 512   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 513.3   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 512   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (195)
POTEE
Tbio
Novelty:  0.29349205
p_int:  0.999956703
p_ni:  0.000043022
p_wrong:  2.74e-7
Score:  0.204
Data Source:  BioPlex,STRINGDB
ALG2
Tbio
Family:  Enzyme
Novelty:  0.03804805
p_int:  0.999793775
p_ni:  0.00012655
p_wrong:  0.000079675
Score:  0.233
Data Source:  BioPlex,STRINGDB
UGT8
Tbio
Family:  Enzyme
Novelty:  0.02518383
p_int:  0.999771249
p_ni:  0.000228751
Score:  0.225
Data Source:  BioPlex,STRINGDB
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.998820445
p_ni:  0.001179555
Data Source:  BioPlex
ADPGK
Tbio
Family:  Kinase
Novelty:  0.0552414
p_int:  0.995220688
p_ni:  0.004779312
Score:  0.449
Data Source:  BioPlex,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.990048761
p_ni:  0.009951239
Score:  0.908
Data Source:  BioPlex,STRINGDB
TMEM214
Tdark
Novelty:  0.32604613
p_int:  0.962386405
p_ni:  0.037613595
Data Source:  BioPlex
PRAF2
Tbio
Novelty:  0.04605835
p_int:  0.959253283
p_ni:  0.040706905
p_wrong:  0.000039812
Data Source:  BioPlex
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.957317575
p_ni:  0.042682408
p_wrong:  1.7e-8
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.947569679
p_ni:  0.052430321
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Heme degradation (R-HSA-189483)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Heme degradation
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Iron uptake and transport
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Heme degradation
Immune System
Innate Immune System
Iron uptake and transport
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
10
19
91.1
waist-hip ratio
4
7
8
79.4
heel bone mineral density
2
3
5
76.5
BMI-adjusted hip circumference
2
4
4
75.8
triglyceride measurement
1
1
1
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
19
91.1
waist-hip ratio
8
79.4
heel bone mineral density
5
76.5
BMI-adjusted hip circumference
4
75.8
triglyceride measurement
1
60.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heme oxygenase 2
VGNC:13713
453880
Macaque
heme oxygenase 2
705461
Mouse
MGI:109373
15369
Rat
RGD:67402
79239
Dog
heme oxygenase 2
VGNC:41720
479864
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heme oxygenase 2
Macaque
heme oxygenase 2
Mouse
Rat
Dog
heme oxygenase 2
Publication Statistics
PubMed Score 513.30
PubMed score by year
PubTator Score 639.64
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title