Tbio HMGXB4 HMG domain-containing protein 4

Protein Summary

Description

Negatively regulates Wnt/beta-catenin signaling during development. High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• Q9UGU5
• O75672
• O75673
• Q9UMT5

Gene Name

• HMGXB4

Ensembl ID

• ENST00000216106
• ENSP00000216106
• ENSG00000100281

Symbol

• HMG2L1
• HMGBCG
• HMG2L1
• HMGBCG
• THC211630

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
transcription factor binding site profile	0.77
transcription factor perturbation	0.68
histone modification site profile	0.63
microRNA	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.8   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 158   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.8   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0