Tbio HMG20A High mobility group protein 20A

Protein Summary

Description

Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).

Uniprot Accession IDs

• Q9NP66
• A6NHY3
• D3DW78
• Q53G31
• Q9NSF6

Gene Name

• HMG20A

Ensembl ID

• ENST00000336216
• ENSP00000336856
• ENSG00000140382
• ENST00000381714
• ENSP00000371133

Symbol

• HMGX1
• HMGXB1
• HMGX1
• HMGXB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.95
kinase perturbation	0.84
transcription factor	0.74
transcription factor perturbation	0.74
biological process	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.64   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.64   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0