Tbio HMG20A High mobility group protein 20A

Protein Summary

Description

Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).

Uniprot Accession IDs

• Q9NP66
• A6NHY3
• D3DW78
• Q53G31
• Q9NSF6

Gene Name

• HMG20A

Ensembl ID

• ENST00000336216
• ENSP00000336856
• ENSG00000140382
• ENST00000381714
• ENSP00000371133

Symbol

• HMGX1
• HMGXB1
• HMGX1
• HMGXB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.95
kinase perturbation	0.84
transcription factor	0.74
transcription factor perturbation	0.74
biological process	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.7   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.7   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (91)

Explore Interacting Targets

1 – 10 of 91

• See Interactions on String-DB

HMG20B

Tbio

Family:  TF

Novelty:  0.05983143

p_int:  1

Score:  0.831

Data Source:  BioPlex,STRINGDB

HDAC1

Tclin

Family:  Epigenetic

Novelty:  0.00065244

p_int:  0.999999998

p_ni:  2e-9

Score:  0.394

Data Source:  BioPlex,STRINGDB

ZC4H2

Tbio

Novelty:  0.04969464

p_int:  0.999999994

p_ni:  3e-9

p_wrong:  3e-9

Score:  0.175

Data Source:  BioPlex,STRINGDB

PHF21A

Tbio

Family:  Epigenetic

Novelty:  0.05904464

p_int:  0.999999993

p_ni:  7e-9

Score:  0.885

Data Source:  BioPlex,STRINGDB

GSE1

Tdark

Novelty:  0.04331197

p_int:  0.999999953

p_ni:  4.6e-8

p_wrong:  1e-9

Score:  0.909

Data Source:  BioPlex,STRINGDB

PHF14

Tbio

Family:  Epigenetic

Novelty:  0.13279118

p_int:  0.999999869

p_ni:  1.26e-7

p_wrong:  6e-9

Score:  0.746

Data Source:  BioPlex,STRINGDB

SFMBT1

Tbio

Family:  Epigenetic

Novelty:  0.00324281

p_int:  0.999998499

p_ni:  2.3e-8

p_wrong:  0.000001478

Score:  0.825

Data Source:  BioPlex,STRINGDB

RCOR2

Tbio

Family:  TF

Novelty:  0.17728151

p_int:  0.999996385

p_ni:  0.000001248

p_wrong:  0.000002367

Score:  0.722

Data Source:  BioPlex,STRINGDB

DTNA

Tbio

Novelty:  0.01165754

p_int:  0.999996078

p_ni:  0.000003921

Score:  0.424

Data Source:  BioPlex,STRINGDB

SNTB1

Tbio

Novelty:  0.05324344

p_int:  0.99999467

p_ni:  0.000005295

p_wrong:  3.5e-8

Score:  0.207

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (5)

Components (1)

Processes (5)

Find Similar Targets

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Non-traceable Author Statement (NAS)	UniProtKB
DNA-binding transcription factor activity	Non-traceable Author Statement (NAS)	UniProtKB
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	12	7	5	1.1	98.3
HbA1c measurement	EFO_0004541	2	2	2		64.8
vitamin D measurement	EFO_0004631	3	1	3		49.5
BMI-adjusted hip circumference	EFO_0008039	1	2	2		46
glucose measurement	EFO_0004468	1	1	1		37.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	5	1.1	98.3
HbA1c measurement	EFO_0004541	2		64.8
vitamin D measurement	EFO_0004631	3		49.5
BMI-adjusted hip circumference	EFO_0008039	2		46
glucose measurement	EFO_0004468	1		37.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Chromatin regulator
Coiled coil
Complete proteome
DNA-binding
Nucleus
Phosphoprotein
Reference proteome
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
coffee consumption measurement
Drugs used in diabetes use measurement
fasting blood glucose measurement
glucose measurement
grip strength measurement
HbA1c measurement
heel bone mineral density
neutrophil count
tea consumption measurement

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	high mobility group 20A	VGNC:3546	453766
Macaque	high mobility group 20A		714893
Mouse	high mobility group 20A	MGI:1914117	66867
Rat	high mobility group 20A	RGD:1564760	315689
Dog	high mobility group 20A	VGNC:41707	487661

Species	Name	OMA	EggNOG	Inparanoid
Chimp	high mobility group 20A
Macaque	high mobility group 20A
Mouse	high mobility group 20A
Rat	high mobility group 20A
Dog	high mobility group 20A

Publication Statistics

PubMed Score 9.70

PubMed score by year

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PubTator Score 4.80

PubTator score by year

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Related Publications

Text Mined References (25)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title