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Tbio
HMG20A
High mobility group protein 20A

Protein Summary
Description
Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336216
  • ENSP00000336856
  • ENSG00000140382
  • ENST00000381714
  • ENSP00000371133

Symbol
  • HMGX1
  • HMGXB1
  • HMGX1
  • HMGXB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
kinase perturbation
0.84
transcription factor
0.74
transcription factor perturbation
0.74
biological process
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.7   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.7   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
HMG20B
Tbio
Family:  TF
Novelty:  0.05983143
p_int:  1
Score:  0.831
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999999998
p_ni:  2e-9
Score:  0.394
Data Source:  BioPlex,STRINGDB
ZC4H2
Tbio
Novelty:  0.04969464
p_int:  0.999999994
p_ni:  3e-9
p_wrong:  3e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
PHF21A
Tbio
Family:  Epigenetic
Novelty:  0.05904464
p_int:  0.999999993
p_ni:  7e-9
Score:  0.885
Data Source:  BioPlex,STRINGDB
GSE1
Tdark
Novelty:  0.04331197
p_int:  0.999999953
p_ni:  4.6e-8
p_wrong:  1e-9
Score:  0.909
Data Source:  BioPlex,STRINGDB
PHF14
Tbio
Family:  Epigenetic
Novelty:  0.13279118
p_int:  0.999999869
p_ni:  1.26e-7
p_wrong:  6e-9
Score:  0.746
Data Source:  BioPlex,STRINGDB
SFMBT1
Tbio
Family:  Epigenetic
Novelty:  0.00324281
p_int:  0.999998499
p_ni:  2.3e-8
p_wrong:  0.000001478
Score:  0.825
Data Source:  BioPlex,STRINGDB
RCOR2
Tbio
Family:  TF
Novelty:  0.17728151
p_int:  0.999996385
p_ni:  0.000001248
p_wrong:  0.000002367
Score:  0.722
Data Source:  BioPlex,STRINGDB
DTNA
Tbio
Novelty:  0.01165754
p_int:  0.999996078
p_ni:  0.000003921
Score:  0.424
Data Source:  BioPlex,STRINGDB
SNTB1
Tbio
Novelty:  0.05324344
p_int:  0.99999467
p_ni:  0.000005295
p_wrong:  3.5e-8
Score:  0.207
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
12
7
5
1.1
98.3
HbA1c measurement
2
2
2
64.8
vitamin D measurement
3
1
3
49.5
BMI-adjusted hip circumference
1
2
2
46
glucose measurement
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1.1
98.3
HbA1c measurement
2
64.8
vitamin D measurement
3
49.5
BMI-adjusted hip circumference
2
46
glucose measurement
1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
high mobility group 20A
VGNC:3546
453766
Macaque
high mobility group 20A
714893
Mouse
MGI:1914117
66867
Rat
RGD:1564760
315689
Dog
high mobility group 20A
VGNC:41707
487661
Species
Name
OMA
EggNOG
Inparanoid
Chimp
high mobility group 20A
Macaque
high mobility group 20A
Mouse
Rat
Dog
high mobility group 20A
Publication Statistics
PubMed Score 9.70
PubMed score by year
PubTator Score 4.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title