Tbio HMCES Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein

Protein Summary

Description

Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).

Uniprot Accession IDs

• Q96FZ2
• A6NJR9
• Q96G34
• Q9NRP3
• ES cell-specific 5hmC-binding protein

Gene Name

• HMCES

Ensembl ID

• ENST00000383463
• ENSP00000372955
• ENSG00000183624
• ENST00000389735
• ENSP00000374385
• ENST00000502878
• ENSP00000426215

Symbol

• C3orf37
• DC12
• SRAPD1
• DC12
• SRAPD1
• C3orf37

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
histone modification site profile	0.9
gene perturbation	0.83
tissue sample	0.7
PubMedID	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.91   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.91   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0