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Tbio
HLX
H2.0-like homeobox protein

Protein Summary
Description
Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366903
  • ENSP00000355870
  • ENSG00000136630

Symbol
  • HLX1
  • HB24
  • HLX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
PubMedID
0.79
protein domain
0.73
transcription factor binding site profile
0.72
gene perturbation
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.82   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.82   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
CEP120
Tbio
Novelty:  0.07215656
p_int:  0.999999998
p_ni:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
TLE2
Tbio
Novelty:  0.03922169
p_int:  0.999897043
p_ni:  0.000102955
p_wrong:  1e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
TLE4
Tbio
Novelty:  0.02094922
p_int:  0.999652562
p_ni:  0.000347438
Score:  0.572
Data Source:  BioPlex,STRINGDB
C18orf25
Tdark
Novelty:  0.67505268
p_int:  0.999451469
p_ni:  0.000548531
Score:  0.217
Data Source:  BioPlex,STRINGDB
TLE1
Tbio
Novelty:  0.00594261
p_int:  0.999450227
p_ni:  0.000549773
Score:  0.202
Data Source:  BioPlex,STRINGDB
AES
Tbio
Novelty:  0.00818499
p_int:  0.999035328
p_ni:  0.000964668
p_wrong:  4e-9
Score:  0.753
Data Source:  BioPlex,STRINGDB
CSNK2A1
Tchem
Family:  Kinase
Novelty:  0.00187855
p_int:  0.993119026
p_ni:  0.006880974
Data Source:  BioPlex
SEPHS1
Tbio
Family:  Enzyme
Novelty:  0.01539662
p_int:  0.986423539
p_ni:  0.013576461
Score:  0.391
Data Source:  BioPlex,STRINGDB
TLE3
Tbio
Novelty:  0.02641884
p_int:  0.977746096
p_ni:  0.022253872
p_wrong:  3.1e-8
Score:  0.182
Data Source:  BioPlex,STRINGDB
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.940262233
p_ni:  0.059737767
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (56)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
15
8
22
97.5
low density lipoprotein cholesterol measurement
20
9
29
97.2
high density lipoprotein cholesterol measurement
37
5
38
95.2
sex hormone-binding globulin measurement
6
4
9
93.7
serum alanine aminotransferase measurement
3
1
2
11.7
91.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
22
97.5
low density lipoprotein cholesterol measurement
29
97.2
high density lipoprotein cholesterol measurement
38
95.2
sex hormone-binding globulin measurement
9
93.7
serum alanine aminotransferase measurement
2
11.7
91.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H2.0 like homeobox
VGNC:10027
469684
Mouse
MGI:96109
15284
Rat
RGD:1311961
364069
Dog
H2.0 like homeobox
VGNC:50302
100682869
Horse
H2.0 like homeobox [Source:HGNC Symbol;Acc:HGNC:4978]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H2.0 like homeobox
Mouse
Rat
Dog
H2.0 like homeobox
Horse
H2.0 like homeobox [Source:HGNC Symbol;Acc:HGNC:4978]
Publication Statistics
PubMed Score 174.82
PubMed score by year
PubTator Score 38.46
PubTator score by year
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Related Publications
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PMID
Year
Title