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Tbio
HLA-G
HLA class I histocompatibility antigen, alpha chain G

Protein Summary
Description
Isoform 1: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110, PubMed:27859042). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:1930479 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360323
  • ENSP00000353472
  • ENSG00000204632
  • ENST00000376815
  • ENSP00000366011
  • ENST00000383621
  • ENSP00000373116
  • ENSG00000206506
  • ENST00000383622
  • ENSP00000373117
  • ENST00000415687
  • ENSP00000389969
  • ENSG00000237216
  • ENST00000423011
  • ENSP00000389522
  • ENSG00000233095
  • ENST00000423373
  • ENSP00000405238
  • ENSG00000235346
  • ENST00000428701
  • ENSP00000412927
  • ENST00000428952
  • ENSP00000388176
  • ENSG00000235680
  • ENST00000429890
  • ENSP00000401326
  • ENST00000444098
  • ENSP00000398200
  • ENSG00000230413
  • ENST00000445373
  • ENSP00000416408
  • ENST00000448306
  • ENSP00000413926
  • ENST00000449127
  • ENSP00000408773
  • ENST00000457132
  • ENSP00000410247
  • ENST00000546545
  • ENSP00000447762
  • ENST00000546634
  • ENSP00000447780
  • ENST00000547241
  • ENSP00000448085
  • ENST00000547931
  • ENSP00000448363
  • ENST00000550897
  • ENSP00000449903
  • ENST00000553052
  • ENSP00000449291
  • ENST00000622601
  • ENSP00000479399
  • ENSG00000276051

Symbol
  • HLA-6.0
  • HLAG
  • MHC-G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
virus perturbation
1
protein domain
0.97
cellular component
0.94
disease
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1370.34   (req: < 5)
Gene RIFs: 641   (req: <= 3)
Antibodies: 1368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1370.34   (req: >= 5)
Gene RIFs: 641   (req: > 3)
Antibodies: 1368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0