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Tbio
HLA-DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

Protein Summary
Description
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374808
  • ENSP00000363941
  • ENSG00000168384
  • ENST00000383224
  • ENSP00000372711
  • ENSG00000206291
  • ENST00000415247
  • ENSP00000405838
  • ENSG00000224103
  • ENST00000419277
  • ENSP00000393566
  • ENSG00000231389
  • ENST00000422504
  • ENSP00000406250
  • ENSG00000228163
  • ENST00000443117
  • ENSP00000397587
  • ENSG00000235844
  • ENST00000454805
  • ENSP00000397139
  • ENSG00000229685
  • ENST00000515317
  • ENSP00000427429
  • ENSG00000236177

Symbol
  • HLA-DP1A
  • HLASB
  • DPA1
  • PLT1
  • HLADP
  • HLASB
  • DP(W3)
  • DP(W4)
  • HLA-DP1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
phenotype
0.84
small molecule perturbation
0.81
cell type or tissue
0.77
disease
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.06   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.06   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (368)
APOE
Tbio
Novelty:  0.00005049
p_int:  0.999998035
p_ni:  0.000001965
Data Source:  BioPlex
NOB1
Tbio
Novelty:  0.01209681
p_int:  0.999990713
p_ni:  0.000009287
Data Source:  BioPlex
DCBLD1
Tbio
Novelty:  0.21754882
p_int:  0.99997869
p_ni:  0.000021306
p_wrong:  3e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
ATP13A2
Tbio
Family:  Transporter
Novelty:  0.00623191
p_int:  0.999927543
p_ni:  0.000072456
p_wrong:  2e-9
Score:  0.15
Data Source:  BioPlex,STRINGDB
FKTN
Tbio
Novelty:  0.00981221
p_int:  0.999699196
p_ni:  0.000300794
p_wrong:  1e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
FUT4
Tbio
Family:  Enzyme
Novelty:  0.00060869
p_int:  0.999565448
p_ni:  0.00000992
p_wrong:  0.000424632
Score:  0.2
Data Source:  BioPlex,STRINGDB
NMU
Tbio
Novelty:  0.00326109
p_int:  0.999414358
p_ni:  0.00058562
p_wrong:  2.2e-8
Data Source:  BioPlex
HBA1
Tclin
Novelty:  0.00094113
p_int:  0.999120943
p_ni:  0.000879057
Data Source:  BioPlex
TYW5
Tbio
Novelty:  0.1382439
p_int:  0.998507026
p_ni:  0.001492961
p_wrong:  1.3e-8
Data Source:  BioPlex
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.997574153
p_ni:  0.00241833
p_wrong:  0.000007517
Data Source:  BioPlex
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
1 – 2 of 2
JAK2
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  7
more:  3 more common pathways
Pathways (51)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream TCR signaling
Reactome
Generation of second messenger molecules
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Downstream TCR signaling
Generation of second messenger molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (456)
Items per page:
1 – 5 of 456
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.6
97.8
4
4
0
1.6
97.8
4
4
0
1.6
97.8
4
4
0
1.6
97.8
4
4
0
1.6
97.8
Items per page:
1 – 5 of 456
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
97.8
0
1.6
97.8
0
1.6
97.8
0
1.6
97.8
0
1.6
97.8
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IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 147.06
PubMed score by year
PubTator Score 110.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title