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Tbio
HLA-DMA
HLA class II histocompatibility antigen, DM alpha chain

Protein Summary
Description
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane doma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374843
  • ENSP00000363976
  • ENSG00000204257
  • ENST00000383230
  • ENSP00000372717
  • ENSG00000243215
  • ENST00000434337
  • ENSP00000407198
  • ENSG00000242361
  • ENST00000441375
  • ENSP00000410591
  • ENSG00000239463
  • ENST00000450601
  • ENSP00000392842
  • ENSG00000242685
  • ENST00000452615
  • ENSP00000395349
  • ENSG00000243189
  • ENST00000453490
  • ENSP00000404018
  • ENSG00000243719

Symbol
  • DMA
  • RING6
  • DMA
  • HLADM
  • RING6
  • D6S222E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.94
gene perturbation
0.8
phenotype
0.77
disease
0.73
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.41   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.41   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (187)
HLA-DMB
Tbio
Novelty:  0.02289537
Score:  0.999
Data Source:  Reactome,STRINGDB
Q95IE3
Tbio
Novelty:  0.00240724
Score:  0.997
Data Source:  STRINGDB
P04229
Tbio
Novelty:  0.00240724
Score:  0.997
Data Source:  STRINGDB
P13761
Tbio
Novelty:  0.00240724
Score:  0.997
Data Source:  STRINGDB
P01911
Tchem
Novelty:  0.00240724
Score:  0.997
Data Source:  STRINGDB
Q30167
Tbio
Novelty:  0.00240724
Score:  0.997
Data Source:  STRINGDB
Q30134
Tbio
Novelty:  0.00240724
Score:  0.997
Data Source:  STRINGDB
P01912
Tbio
Novelty:  0.00240724
Score:  0.997
Data Source:  STRINGDB
Q29974
Tbio
Novelty:  0.00240724
Score:  0.997
Data Source:  STRINGDB
Q9TQE0
Tbio
Novelty:  0.00240724
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
1 – 2 of 2
JAK2
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  7
more:  3 more common pathways
Pathways (31)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
MHC class II antigen presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
MHC class II antigen presentation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (155)
Items per page:
1 – 5 of 155
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.4
93.2
2
2
0
1.4
93.2
2
2
0
1.4
93.2
2
2
0
1.4
93.2
2
2
0
1.4
93.2
Items per page:
1 – 5 of 155
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
93.2
0
1.4
93.2
0
1.4
93.2
0
1.4
93.2
0
1.4
93.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95921
14998
Dog
major histocompatibility complex, class II, DM alpha
481732
Pig
SLA-DM alpha chain
445528
Xenopus
major histocompatibility complex class II alpha chain precursor
XB-GENE-481445
100495336
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
major histocompatibility complex, class II, DM alpha
Pig
SLA-DM alpha chain
Xenopus
major histocompatibility complex class II alpha chain precursor
Publication Statistics
PubMed Score 253.41
PubMed score by year
PubTator Score 102.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title